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Histopathological examination of a biopsy specimen from this lymph node showed that small cell carcinoma of the lung was present. The patient's deficits were subsequently diagnosed as three coexisting paraneoplastic neurological syndromes (PNSs): subacute cerebellar ataxia, sensory neuropathy and retinopathy, respectively. Although rare, PNSs can be the first manifestations of cancer, and their rapid recognition facilitates an early treatment.<\/jats:p>","DOI":"10.1136\/bcr-2012-008432","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T04:24:04Z","timestamp":1360211044000},"page":"bcr2012008432","source":"Crossref","is-referenced-by-count":7,"title":["Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung"],"prefix":"10.1136","volume":"2013","author":[{"given":"L\u00e9nea","family":"Porto","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mafalda","family":"Miranda","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gomes","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Neurology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJM198712173172509","article-title":"Paraneoplastic syndromes: a window on the biology of cancer","volume":"317","author":"Abeloff","year":"1987","journal-title":"N Engl J Med"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0099"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.3","first-page":"687","article-title":"Paraneoplastic syndromes in lung cancer","volume":"6","author":"Heinemann","year":"2008","journal-title":"Cancer Ther"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.4","first-page":"440","article-title":"Cancer de pulm\u00f3n y syndromes paraneopl\u00e1sicos","volume":"18","author":"G\u00e1mez","year":"2001","journal-title":"An Med Interna"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023009"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034447"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.7","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-22"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.9.764"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1279"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.05.014"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.159483"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00442-7"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1445-5994.1991.tb00447.x","article-title":"Monoclonal immunoglobulin bands in the cerebrospinal fluid","volume":"21","author":"McCombe","year":"1991","journal-title":"Aust N Z J Med"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.14","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0099"},{"key":"2025082700042852000_2013.feb06_1.bcr2012008432.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01266.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2012-008432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:04:37Z","timestamp":1756278277000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2012-008432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":15,"alternative-id":["10.1136\/bcr-2012-008432"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2012-008432","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}