{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:10:03Z","timestamp":1756293003577,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Stroke has been recognised more frequently in children and represents a major cause of morbidity and mortality. It usually has an acute presentation, characterised by focal neurological signs, headache, altered state of consciousness or seizures. We report the case of an 18-month-male child with motor development disturbance, gait difficulty and preferential use of the left arm with right hemiparesis at clinical exam. Brain MRI showed an extensive damage involving corona radiata, thalamus, posterior arm of the internal capsule and left lenticular nucleus with atrophic retraction of the adjacent cerebrospinal fluid pathways, suggesting old ischaemic injury of the middle cerebral artery territory. Causal research pointed out at methyltetrahydrofolate reductase (MTHFR) C677T heterozygosity. He was referenced to physiotherapy and paediatric neurology consultation with favourable evolution and no recurrence of ischaemic events. Stroke is a relatively rare phenomenon in children; however, we have to consider it as a diagnosis in the presence of focal neurological deficits. MTHFR C677T mutation is considered a prothrombotic factor; however, in the absence of hyperhomocysteinaemia, no direct therapeutic approach is necessary.<\/jats:p>","DOI":"10.1136\/bcr-2013-008835","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T23:36:13Z","timestamp":1370561773000},"page":"bcr2013008835","source":"Crossref","is-referenced-by-count":0,"title":["Disturbance of motor development: a manifestation of stroke in early childhood"],"prefix":"10.1136","volume":"2013","author":[{"given":"R S","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hospital S\u00e3o Teot\u00f3nio-Centro Hospitalar Tondela Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nobre","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Pediatrico Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital S\u00e3o Teot\u00f3nio-Centro Hospitalar Tondela Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital S\u00e3o Teot\u00f3nio-Centro Hospitalar Tondela Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.1","doi-asserted-by":"crossref","unstructured":"Lanni G Catalucci A Conti L . Pediatric stroke: clinical findings and radiologic approach. Stroke Res Treat 2011;172168.","DOI":"10.4061\/2011\/172168"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/adc.2008.142836","article-title":"Cerebrovascular disease and stroke","volume":"2013","author":"Pappacham","year":"2008","journal-title":"Arch Dis Child"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.3","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1161\/STROKEAHA.108.189696","article-title":"Management of stroke in infants and children: a scientific statement from a special writing group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young","volume":"2013","author":"Roach","year":"2008","journal-title":"Stroke"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.4","first-page":"1629","article-title":"Intracranial hemorrhage in children","volume":"2013","author":"Lo","year":"2008","journal-title":"Arch Neurol"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pediatrneurol.2009.04.017","article-title":"Methylenetetrahydrofolate reductase gene polymorphism and childhood stroke","volume":"2013","author":"Morita","year":"2009","journal-title":"Pediatr Neurol"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/0883073810381446","article-title":"Role of methylenetetrahydrofolate reductase gene (MTHFR)677C>T polymorphism in pediatric cerebrovascular disorders","volume":"2013","author":"Alsayouf","year":"2011","journal-title":"J Child Neurol"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.7","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/01.STR.0000106669.19525.0F","article-title":"Editorial comment\u2014specificities ofthe neonatal stroke","volume":"2013","author":"Chabrier","year":"2003","journal-title":"Stroke"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.8","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1542\/peds.114.2.e206","article-title":"Pediatric stroke among Hong Kong Chinese subjects","volume":"2013","author":"Chung","year":"2004","journal-title":"Pedaitrics"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.9","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1542\/peds.2007-0502","article-title":"Association between iron-deficiency anemia and stroke in young children","volume":"2013","author":"Maguire","year":"2007","journal-title":"Pediatrics"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00381-011-1618-3","article-title":"The importance of MTHFR polymorphisms in pediatric cerebral stroke","volume":"2013","author":"Unal","year":"2012","journal-title":"Childs Nerv Syst"},{"key":"2025082703333546000_2013.jun06_1.bcr2013008835.11","unstructured":"Kliegman R . Pediatric stroke syndromes. In: Nelson textbook of pediatrics. 19th edn. Saunders: Chapter 594."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-008835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:33:43Z","timestamp":1756290823000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-008835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":11,"alternative-id":["10.1136\/bcr-2013-008835"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-008835","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,6,6]]}}}