{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:38:56Z","timestamp":1762875536263,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Stevens\u2013Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine (CBZ) has been commonly implicated in SJS. Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. Among the neuroleptics, haloperidol (parenteral) is implicated as a most common drug for NMS. Though rare, association of NMS with CBZ and association of NMS with toxic epidermal necrolysis (TEN) in a single patient after administration of neuroleptics has been reported in the literature before. However, a combination of NMS and SJS in a single patient after administration of CBZ has not been reported so far. We present a patient with seizure who developed SJS and NMS following administration of CBZ.<\/jats:p>","DOI":"10.1136\/bcr-2013-008908","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T02:04:32Z","timestamp":1371002672000},"page":"bcr2013008908","source":"Crossref","is-referenced-by-count":5,"title":["Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence"],"prefix":"10.1136","volume":"2013","author":[{"given":"Bhawna","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavendra Bakki","family":"Sannegowda","sequence":"additional","affiliation":[{"name":"Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Manipal Hospitals, Goa, Goa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Panagariya","sequence":"additional","affiliation":[{"name":"Department of Neurology, SMS Medical College Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.1","first-page":"48","article-title":"Stevens-Johnson syndrome following treatment with carbamazepine for a mood disorder","volume":"2013","author":"Coleman","year":"1996","journal-title":"Jefferson J Psychiatry"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eci.11.66","article-title":"The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"2013","author":"Mockenhaupt","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.3","unstructured":"Frisch PO Ruiz-Maldonado R . Erythema multiforme, Stevens Johnson syndrome and toxic epidermal necrolysis. In: Freedberg IM Eisen AZ Wolff K Austen KF Goldsmith LA Katz SI , eds. Fitzpatrick's dermatology in general medicine. 6th edn. New York: McGraw-Hill, 2003:543\u201357."},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/archderm.1990.01670250043005","article-title":"Toxic epidermal necrolysis (Lyell syndrome). Incidence and drug etiology in France, 1981\u20131985","volume":"2013","author":"Roujeau","year":"1990","journal-title":"Arch Dermatol"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4103\/0378-6323.16782","article-title":"Carbamazepine\u2014The commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: a study of 7\u2005years","volume":"2013","author":"Devi","year":"2005","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/CCM.0b013e31821201ed","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome: a review","volume":"2013","author":"Gerull","year":"2011","journal-title":"Crit Care Med"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.7","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.jaci.2011.12.990","article-title":"Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome","volume":"2013","author":"Wei","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14740330903427969","article-title":"Genetic predisposition of life-threatening antiepileptic-induced skin reactions","volume":"2013","author":"Chung","year":"2010","journal-title":"Expert Opin Drug Saf"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.9","first-page":"5","article-title":"Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome","volume":"2013","author":"Ghislain","year":"2012","journal-title":"Dermatol Online J"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0028-3886.32793","article-title":"The neuroleptic malignant syndrome: a report of 14 cases from North India","volume":"2013","author":"Panagariya","year":"2007","journal-title":"Neurol India"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.11","first-page":"91","article-title":"Management of neuroleptic malignant syndrome\u2014a series of eight cases","volume":"2013","author":"Kurien","year":"1993","journal-title":"J Assoc Physicians India"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1212\/WNL.31.2.132","article-title":"Neuroleptic malignant syndrome: a pathogenetic role for dopamine receptor blockade?","volume":"2013","author":"Henderson","year":"1981","journal-title":"Neurology"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.13","doi-asserted-by":"crossref","first-page":"E834","DOI":"10.1503\/cmaj.091442","article-title":"Neuroleptic malignant syndrome: a neuroimmunologic hypothesis","volume":"2013","author":"Anglin","year":"2010","journal-title":"CMAJ."},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0140-6736(91)90138-F","article-title":"Serum iron and neuroleptic malignant syndrome","volume":"2013","author":"Rosebush","year":"1991","journal-title":"Lancet"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.15","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1471-4159.1985.tb05514.x","article-title":"Effect of iron chelators on dopamine D2 receptors","volume":"2013","author":"Ben-Shachar","year":"1985","journal-title":"J Neurochem"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.16","first-page":"53","article-title":"Neuroleptic malignant syndrome, with attention to its occurrence with atypical antipsychotic medication: a review","volume":"2013","author":"Guzofski","year":"2006","journal-title":"Jefferson J Psychiatry"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.17","first-page":"129","article-title":"Horber-Neuroleptic malignant syndrome","volume":"2013","author":"Adnet","year":"1985","journal-title":"Br J Anaesthesia"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.18","first-page":"25","article-title":"Neuroleptic malignant syndrome\u201d","volume":"2013","author":"Caroff","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"2025082702270976000_2013.jun11_1.bcr2013008908.19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00005792-200007000-00001","article-title":"Serotonin syndrome. 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