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Both were clinically euthyroid but with free hormone excess and suppressed thyroid stimulating hormone (TSH) on laboratory testing. Both patients received methimazole prior to thyroidectomy. Histopathology revealed follicular variant of papillary cancer with metastasis to the manubrium for the first patient and follicular thyroid cancer with lymph node metastasis for the second. While rare, thyrotoxicosis can occur with malignancy, Plummer's disease may harbour cancer and behave aggressively.<\/jats:p>","DOI":"10.1136\/bcr-2013-008909","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T07:25:17Z","timestamp":1362209117000},"page":"bcr2013008909","source":"Crossref","is-referenced-by-count":2,"title":["Thyroid cancer in Plummer's disease"],"prefix":"10.1136","volume":"2013","author":[{"given":"Queenie Guinto","family":"Ngalob","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines\u2014Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris Thiele","family":"Isip-Tan","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines\u2014Philippine General Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.2.130"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.12.006"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70480-2"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.4","first-page":"244","article-title":"Thyroid nodules in Graves\u2019 disease: implications in an endemically iodine deficient area","volume":"47","author":"Mishra","year":"2001","journal-title":"J Postgrad Med"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471414"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0136"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.7","first-page":"23","article-title":"Hyperthyroidism and carcinoma of the thyroid gland","volume":"68","author":"Ardito","year":"1997","journal-title":"Ann Ital Chir"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0468"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.9","first-page":"29","article-title":"Thyrotoxicosis and thyroid cancer","volume":"57","author":"Zaslavskaia","year":"1985","journal-title":"Ter Arkh"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.10","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.11","doi-asserted-by":"publisher","DOI":"10.4158\/10024.GL"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.15605\/jafes.027.01.19","article-title":"A case of toxic multinodular goiter and anaplastic carcinoma","volume":"27","author":"Adorable-Wagan","year":"2012","journal-title":"JAFES"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.13","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1340366"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299741"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.15","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.33855"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2007.00108.x"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.17","first-page":"91","article-title":"Clinical presentation and treatment of hyperthyroidism associated with thyroid cancer","volume":"39","author":"Taneri","year":"2005","journal-title":"Endocr Regul"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.18","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630914"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.19","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.30605"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF03401510","article-title":"Autonomously functioning thyroid nodule treated with radioactive iodine and later diagnosed as papillary thyroid cancer","volume":"7","author":"Uludag","year":"2008","journal-title":"Hormones"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.21","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0144"},{"key":"2025082722174627000_2013.mar01_1.bcr2013008909.22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ajcp\/101.1.29","article-title":"1994 Autonomously functioning (hot) nodule of the thyroid gland. 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