{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:58Z","timestamp":1772169178326,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Ehlers-Danlos syndrome (EDS) comprises a group of hereditary connective tissue disorders in which collagen synthesis and fibrogenesis are impaired. Patients with EDS type III have a bleeding tendency manifested by ecchymoses and haematomas. However, thrombotic events are rare in this entity. Herein, we present a 48-year-old Hispanic man with EDS type III who had recurrent cephalic vein thrombophlebitis and thrombosis, and brachial vein thrombosis. Tests for hypercoagulable disorders including antithrombin III activity, protein C activity, protein S activity, anticardiolipin antibodies, homocysteine levels, factor V Leiden mutation and prothrombin gene mutation were negative. The patient required long-term anticoagulation with warfarin. After 3\u2005years follow-up, he did not present further thrombotic events. Clinicians should be aware that patients with EDS might be at risk for hypercoagulable disorders.<\/jats:p>","DOI":"10.1136\/bcr-2013-008922","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T08:19:49Z","timestamp":1372407589000},"page":"bcr2013008922","source":"Crossref","is-referenced-by-count":5,"title":["Recurrent venous thrombosis in Ehlers-Danlos syndrome type III: an atypical manifestation"],"prefix":"10.1136","volume":"2013","author":[{"given":"Esther","family":"Jim\u00e9nez-Encarnaci\u00f3n","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M","family":"Vil\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.1","unstructured":"Mckusick VA . The Ehlers-Danlos syndrome in heritable disorders of connective tissue. 4th edn. Mosby, 1972:292\u2013371."},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.2","first-page":"130","article-title":"Acquired and heritable defects in collagen synthesis and fibrogenesis","volume":"2013","author":"McKusick","year":"1974","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.3","unstructured":"Beighton P . The Ehlers-Danlos syndromes. In: McKusick VA Beighton P , eds. McKusick's heritable disorders of connective tissue. 5th edn. Mosby-Year Book, 1993:189\u201393."},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ajmg.a.33231","article-title":"Natural history and manifestations of the hypermobility type Ehlers-Danlos syndrome: a pilot study on 21 patients","volume":"2013","author":"Castori","year":"2010","journal-title":"Am J Med Genet A"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jvs.2005.03.053","article-title":"The spectrum, management and clinical outcome of Ehlers-Danlos syndrome type IV: a 30-year experience","volume":"2013","author":"Oderich","year":"2005","journal-title":"J Vasc Surg"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1055\/s-2001-14074","article-title":"Clinical study of venous thromboembolism during pregnancy and puerperium","volume":"2013","author":"Adachi","year":"2001","journal-title":"Semin Thromb Hemost"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.7","first-page":"2091","article-title":"Ehlers-Danlos syndrome type IV in a young man","volume":"2013","author":"Asherson","year":"2006","journal-title":"J Rheumatol"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.8","first-page":"52","article-title":"Spontaneous superficial venous thrombophlebitis: does it increase risk for thromboembolism? A historic follow-up study in primary care","volume":"2013","author":"Van Weert","year":"2006","journal-title":"J Fam Pract"},{"key":"2025082701482812000_2013.jun27_1.bcr2013008922.9","first-page":"279","article-title":"Upper extremity deep vein thrombosis related to fatal massive pulmonary embolism after spinal surgery","volume":"2013","author":"Oofuvong","year":"2012","journal-title":"J Med Assoc Thai"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-008922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:48:38Z","timestamp":1756284518000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-008922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":9,"alternative-id":["10.1136\/bcr-2013-008922"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-008922","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}