{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:05:28Z","timestamp":1778717128236,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The aim of the paper is to report the case of a boy affected by cystic fibrosis, with non-ABPA-related recurrent wheezing and frequent pulmonary exacerbation during childhood, who had been \u00a0inhaling 7% NaCl+0.1% hyaluronic acid (HA) as a maintenance therapy. We reviewed patient database and, analysing a 7-year follow-up, considered pulmonary exacerbation, antibiotic and steroid courses, pulmonary function (forced expiratory volume in one second; FEV<jats:sub>1<\/jats:sub>) and microbiological data. After starting 7% NaCl+0.1% HA treatment, we observed a dramatic decrease of oral antibiotic need (0.55 courses\/month during the pretreatment period against 0.10 courses\/month in the treatment period), associated with a good initial recovery and a stability of FEV<jats:sub>1<\/jats:sub>. In our opinion this case could suggest an extended indication for inhaled 7% NaCl+0.1% HA use in CF, not only in patients who did not tolerate hypertonic saline, but also in patients with coexistent asthma-like symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2013-009042","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T05:10:53Z","timestamp":1367298653000},"page":"bcr2013009042","source":"Crossref","is-referenced-by-count":7,"title":["Inhaled hypertonic saline+hyaluronic acid in cystic fibrosis with asthma-like symptoms: a new therapeutic 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