{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:26:47Z","timestamp":1756463207055,"version":"3.40.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Vitamin B<jats:sub>12<\/jats:sub>deficiency has a wide spectrum of clinical presentation with a variety of neurological symptoms and signs. As a result, many patients lack classic features of advanced severe deficiency. Early diagnosis and treatment are crucial in order to prevent the irreversible damage to the nervous system. We describe a 25-year-old man, who presented with predominant sensory symptoms without any signs on clinical evaluation. His serum vitamin B<jats:sub>12<\/jats:sub>levels were low and neuroimaging revealed myelopathy. The patient was treated promptly with cyanocobalamin injections, which lead to a rapid resolution of symptoms and radiological abnormalities.<\/jats:p>","DOI":"10.1136\/bcr-2013-009090","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T04:06:46Z","timestamp":1369714006000},"page":"bcr2013009090","source":"Crossref","is-referenced-by-count":3,"title":["Early treatment causes clinicoradiological reversal of myelopathy due to vitamin B<sub>12<\/sub>deficiency"],"prefix":"10.1136","volume":"2013","author":[{"given":"Rajesh","family":"Verma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Kori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar B","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heramba Narayan","family":"Praharaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"2025042708055127000_2013.may27_1.bcr2013009090.1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s002340050610","article-title":"A case of subacute combined degeneration: MRI findings","volume":"2013","author":"Yamada","year":"1998","journal-title":"Neuroradiology"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.2","unstructured":"Duchen LW Jacobs JM . Nutritional deficiencies and metabolic disorders, vitamin B12. In: Adams JH Duchen LW , eds. Greenfield's neuropathology. 5th edn. London: Edward Arnold, 1992:826\u201332."},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0950-3536(05)80225-2","article-title":"Neurological complications of acquired cobalamin deficiency: clinical aspects","volume":"2013","author":"Savage","year":"1995","journal-title":"Ballieres Clin Haematol"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.4","first-page":"60","article-title":"MRI in vitamin B12 deficiency myelopathy","volume":"2013","author":"Locatelli","year":"1999","journal-title":"Can J Neurol Sci"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/jnnp.62.1.99","article-title":"MRI appearances in subacute combined degeneration of the spinal cord due to vitamin B12 deficiency","volume":"2013","author":"Larner","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0009-9260(97)80138-9","article-title":"Case report: MR appearances in vitamin B12 neuropathy","volume":"2013","author":"Ng","year":"1997","journal-title":"Clin Radiol"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/jnnp.62.3.298","article-title":"MRI demonstration of reversible impairment of the blood-CNS barrier function in subacute combined degeneration of the spinal cord","volume":"2013","author":"Kuker","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Suppl 1","key":"2025042708055127000_2013.may27_1.bcr2013009090.8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02278134","article-title":"Spinal MRI in progressive myeloneuropathy associated with vitamin E deficiency","volume":"2013","author":"Vorgerd","year":"1996","journal-title":"Neuroradiology"},{"key":"2025042708055127000_2013.may27_1.bcr2013009090.9","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1016\/S0149-2918(03)90096-8","article-title":"Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study","volume":"2013","author":"Bolaman","year":"2003","journal-title":"Clin Ther"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:05:58Z","timestamp":1745766358000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,27]]},"references-count":9,"alternative-id":["10.1136\/bcr-2013-009090"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009090","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,5,27]]}}}