{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:40:07Z","timestamp":1745772007066,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Neonatal meningitis is a serious disease with signi\ufb01cant mortality and morbidity. Its signs and symptoms are subtle, non-specific, atypical or absent. Cephalohaematoma is frequent in newborns and complications are uncommon, including local infection after haematogenous spread in the setting of bacteraemia or meningitis with a possibility of osteomyelitis, epidural abscess and subdural empyema. We report the case of a late preterm newborn, with an unremarkable pregnancy, born by vacuum-assisted vaginal delivery that presented in the fifth day of life with irritability, fever and grunting. Cerebrospinal fluid and blood cultures were positive for<jats:italic>Escherichia coli<\/jats:italic>. The patient had neurological deterioration despite adequate antibiotic therapy and brain MRI showed a right parietal epidural empyema, subcutaneous abscess, osteomyelitis and supratentorial hydrocephalus. The culture of the cephalohaematoma's abscess material was positive for<jats:italic>E coli<\/jats:italic>. Antibiotic therapy was continued for 8\u2005weeks. The child, now 2\u2005years old, has spastic tetraparesis with global development delay.<\/jats:p>","DOI":"10.1136\/bcr-2013-009149","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T14:19:12Z","timestamp":1377267552000},"page":"bcr2013009149","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal meningitis associated with osteomyelitis and epidural empyema"],"prefix":"10.1136","volume":"2013","author":[{"given":"Beatriz","family":"Vale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Resende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaide","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.1","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1136\/fn.88.3.F173","article-title":"Neonatal meningitis","volume":"2013","author":"Heath","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/QCO.0b013e32832ad49e","article-title":"Improving the outcome of neonatal meningitis","volume":"2013","author":"Galiza","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/0009922809335669","article-title":"Escherichia coli-infected cephalohematoma in an infant","volume":"2013","author":"Weiss","year":"2009","journal-title":"Clin Pediatr."},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1442-200x.2005.02062.x","article-title":"Infected cephalohematoma of newborns: experience in a medical center in Taiwan","volume":"2013","author":"Chang","year":"2005","journal-title":"Pediatr Int"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.5","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1086\/342304","article-title":"Escherichia hermanii infection of a cephalohematoma: case report, review of the literature, and description of a novel invasive pathogen","volume":"2013","author":"Dahl","year":"2002","journal-title":"Clin Infect Dis"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.6","doi-asserted-by":"crossref","unstructured":"Mangurten HH, Puppala BL. Birth injuries. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. 9th edn. Philadelphia: Elsevier, 2010:501\u201330.","DOI":"10.1016\/B978-0-323-06545-0.00037-6"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.7","first-page":"217","article-title":"Infected cephalohematoma complicated with meningitis: report of one case","volume":"2013","author":"Huang","year":"2002","journal-title":"Acta Paediatr Taiwan"},{"key":"2025042709065944000_2013.aug23_1.bcr2013009149.8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jmii.2011.12.034","article-title":"Factors for poor prognosis of neonatal bacterial meningitis in a medical center in Northern Taiwan","volume":"2013","author":"Lin","year":"2012","journal-title":"J Microbiol Immunol Infect"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:07:11Z","timestamp":1745770031000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,23]]},"references-count":8,"alternative-id":["10.1136\/bcr-2013-009149"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009149","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,8,23]]}}}