{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:23:44Z","timestamp":1786242224003,"version":"build-2736575974"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The following report describes two male patients with an ongoing medical history with a predominant laryngeal focus, who were finally diagnosed with IgG4-related disease (IgG4-RD). Their primary symptoms included hoarseness and pain of the throat, and they had undergone multiple laryngeal surgeries and laser treatments due to tumorous growth with limited success. Due to the onset of additional symptoms, they initially received the diagnoses granulomatous polyangiitis (GPA) and Beh\u00e7et's disease. However, further analysis showed elevated IgG4 levels in serum and infiltration of IgG4-positive plasma cells upon biopsy of laryngeal and pulmonary tissue. Treatment was started with moderate doses of prednisone, leading to a rapid resolution of symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2013-009158","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T15:42:19Z","timestamp":1372434139000},"page":"bcr2013009158","source":"Crossref","is-referenced-by-count":20,"title":["IgG4-related disease with atypical laryngeal presentation and Beh\u00e7et\/granulomatous polyangiitis mimicking features"],"prefix":"10.1136","volume":"2013","author":[{"given":"Yasmin","family":"Shaib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Ton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Goldschmeding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Tekstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00535-003-1175-y","article-title":"A new clinicopathological entity of IgG4-related autoimmune disease","volume":"2013","author":"Kamisawa","year":"2003","journal-title":"J Gastroenterol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/BOR.0b013e3283412fd4","article-title":"What is IgG4? A review of the biology of a unique immunoglobin subtype","volume":"2013","author":"Nirula","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"2013","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.4","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/ar3924","article-title":"Analysis of IgG4 class switch-related molecules in IgG4-related disease","volume":"2013","author":"Tsuboi","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.5","first-page":"789164","article-title":"IgG4-related fibrotic diseases from an immunological perspective: regulators out of control?","volume":"2013","author":"Lighaam","year":"2012","journal-title":"Int J Rheumatol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/BOR.0b013e328341a240","article-title":"Treatment approaches to IgG4-related systemic disease","volume":"2013","author":"Khosroshahi","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.7","doi-asserted-by":"crossref","unstructured":"Khosroshahi A Stone JH . A clinical overview of IgG4-related disease. Curr Opin Rheumatol 2011;2357\u201366.","DOI":"10.1097\/BOR.0b013e3283418057"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.berh.2012.07.001","article-title":"IgG4-related disease","volume":"2013","author":"Guma","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/archoto.2012.1821","article-title":"IgG4-sclerosing pseudotumor of the trachea: a case report and review of the literature","volume":"2013","author":"Virk","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/s10165-011-0571-z","article-title":"Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD)","volume":"2013","author":"Umehara","year":"2012","journal-title":"Mod Rheumatol"},{"key":"2025042708220303000_2013.jun21_1.bcr2013009158.11","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/art.27435","article-title":"Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease","volume":"2013","author":"Khosroshahi","year":"2010","journal-title":"Arthritis Rheumatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:22:09Z","timestamp":1745767329000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":11,"alternative-id":["10.1136\/bcr-2013-009158"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009158","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}