{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:01:49Z","timestamp":1767859309497,"version":"3.49.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The McKittrick-Wheelock syndrome, a rare disorder, is caused by fluid and electrolyte hypersecretion from a rectal tumour and patients can develop a depletion syndrome characterised by severe dehydration, hyponatraemia, hypokalaemia and metabolic acidosis. We present a case of a 62-year-old man who presented with chronic diarrhoea that had resulted in numerous previous hospital admissions. On physical exam, the patient showed signs of volume depletion. A soft polypoid mass was appreciated on digital rectal examination. Laboratory tests showed renal failure and significant electrolyte abnormalities. Colonoscopy revealed a large, friable mass in the rectosigmoid region. Biopsies were consistent with tubolovillous adenoma. Subsequently, the patient underwent surgical resection, which on pathology exhibited evidence of high-grade dysplasia, and the patient was diagnosed with McKittrick-Wheelock syndrome. It is essential to identify this condition in a timely manner as it is associated with high morbidity and complications, some of which may be life threatening.<\/jats:p>","DOI":"10.1136\/bcr-2013-009208","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T01:34:27Z","timestamp":1366076067000},"page":"bcr2013009208","source":"Crossref","is-referenced-by-count":8,"title":["The McKittrick-Wheelock syndrome: a rare cause of chronic diarrhoea"],"prefix":"10.1136","volume":"2013","author":[{"given":"Jana G","family":"Hashash","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Holder-Murray","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Colon and Rectal Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Aoun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, West Penn Allegheny Health System, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhiraj","family":"Yadav","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/archsurg.1958.01290020098019","article-title":"Villous papilloma of the rectum with severe fluid and electrolyte depletion","volume":"2013","author":"Jordan","year":"1958","journal-title":"AMA Arch Surg"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.2","unstructured":"McKittrick LS Wheelock FC Jr . Carcinoma of the colon. Springfield, IL, Charles C Thomas, 1954;61\u20133."},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/08860220801964277","article-title":"The McKittrick-Wheelock syndrome: a case of acute renal failure due to neoplastic cholera","volume":"2013","author":"Winstanley","year":"2008","journal-title":"Ren Fail"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.4","first-page":"e171","article-title":"McKittrick-Wheelock syndrome: a rare cause of life-threatening electrolyte disturbances and volume depletion","volume":"2013","author":"Lee","year":"2010","journal-title":"J Emerg Med"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s003840050103","article-title":"Risk of invasive carcinoma in colorectal adenomas assessed by size and site","volume":"2013","author":"Nusko","year":"1997","journal-title":"Int J Colorectal Dis"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0090-6980(92)90116-B","article-title":"Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin","volume":"2013","author":"Smelt","year":"1992","journal-title":"Prostaglandins"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/archinte.159.8.879","article-title":"Secretory villous adenomas that cause depletion syndrome","volume":"2013","author":"Older","year":"1999","journal-title":"Arch Intern Med"},{"key":"2025082801360947000_2013.apr15_1.bcr2013009208.8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/SLE.0b013e31818135ad","article-title":"McKittrick-Wheelock syndrome treated by laparoscopy: report of 3 cases","volume":"2013","author":"Targarona","year":"2008","journal-title":"Surg Laparosc Endosc Percutan Tech"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:36:20Z","timestamp":1756370180000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":8,"alternative-id":["10.1136\/bcr-2013-009208"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009208","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}