{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:26:24Z","timestamp":1763036784077,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Papillary cystadenocarcinoma (PCC) is an uncommon malignant tumour of the salivary gland, sometimes involving the minor salivary gland. Previously this entity was classified as an atypical type of adenocarcinoma, malignant papillary cystadenoma, low-grade papillary adenocarcinoma or mucus producing adenopapillary carcinoma. PCC is a glandular tumour with an indolent biological behaviour characterised by cysts and papillary endophytic projections. We report two cases of PCC involving the minor salivary gland of the hard palate. Both the patients presented with a swelling in the palate with difficulty in chewing. MRI revealed an extensively destructive lesion involving hard palate, alveolar ridge and maxillary antrum. Clinical and radiological features suggested the malignant nature of the lesion. Histopathology of incisional biopsy revealed tumour proliferation in a multicystic pattern, with extensive papillary proliferation. Diverse and cellular cytomorphology, and cellular and nuclear pleomorphism with few mitotic figures were the prominent features. Both the lesions were confirmed as PCC.<\/jats:p>","DOI":"10.1136\/bcr-2013-009215","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T16:07:55Z","timestamp":1389283675000},"page":"bcr2013009215","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Papillary cystadenocarcinoma of the hard palate"],"prefix":"10.1136","volume":"2014","author":[{"given":"Sangeeta Panjab","family":"Wanjari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panjab Vitthalrao","family":"Wanjari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana A","family":"Patidar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajkumar N","family":"Parwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00522.x"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.2","unstructured":"Dardick I , ed. Color atlas\/text of salivary gland tumor pathology. New York: Igaku-Shoin medical publishers, 1996:231."},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.3","first-page":"20","article-title":"MRI findings of papillary cystadenocarcinoma of the submandibular gland","volume":"16","author":"Koc","year":"2010","journal-title":"Diagn Interv Radiol"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2006.07.010"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.5","doi-asserted-by":"crossref","unstructured":"Peel RL Seethala RR . Pathology of salivary gland disease. In: Myers EN Ferris RL , eds. Salivary gland disorders. USA: Springer, 2007:33\u2013104.","DOI":"10.1007\/978-3-540-47072-4_3"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.6","doi-asserted-by":"crossref","unstructured":"Aloudah NM, Raddaoui E, Aldhahri S, et al. Low grade papilllary cystadenocarcinoma of the parotid gland: Presentation of a case with cytological, histopathological and immunohistochemical features and pertinent literature review. Diagn Cytopathol 2009,37:128\u201331.","DOI":"10.1002\/dc.20971"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0714.1999.tb02040.x","article-title":"Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland","volume":"28","year":"1999","journal-title":"J Oral Pathol Med"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.8","doi-asserted-by":"publisher","DOI":"10.3353\/omp.6.103"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.07.006"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.9.834"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.11","unstructured":"Fletcher CDM , ed. Diagnostic histopathology of tumors. USA: Churchill Livingstone Elsevier, 2007:239."},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.12","doi-asserted-by":"crossref","unstructured":"Grunstein E, Kacker A. Salivary gland cystadenocarcinoma of the mobile tongue, low grade papillary adenocarcinoma variant: A case report. Ear Nose Throat J 2006;85:829\u201330.","DOI":"10.1177\/014556130608501215"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.13","unstructured":"Kumar V Abbas AK Fausto N , eds. Robbins and Cotran: pathologic basis of disease. Philadelphia: Elsevier, 2004:1096."},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.14","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2006.0072"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.15","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.38615"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.16","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.112247"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.17","unstructured":"Cawson RA Binnie WH Speight PM . eds. Lucas's pathology of tumors of the oral tissues. New York: Churchill Livingstone, 1998:385."},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.18","unstructured":"Cawson RA Gleeson MI Eveson JW . Carcinoma of salivary Glands. In: Cawson RA , ed. Pathology and surgery of the salivary glands. UK: Isis Medical Media Ltd, 1997:117."},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.19","doi-asserted-by":"publisher","DOI":"10.1590\/S1676-24442008000300008"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.20","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0082-1"},{"key":"2025042702094881000_2014.jan09_2.bcr2013009215.21","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.115978"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:10:00Z","timestamp":1745745000000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,9]]},"references-count":21,"alternative-id":["10.1136\/bcr-2013-009215"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009215","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,1,9]]}}}