{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:17Z","timestamp":1756339397068,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,6,23]]},"abstract":"<jats:p>We report a case of a man presenting with an unexplained fever, pancytopenia and hepatosplenomegaly without lymphadenopathy. Bone marrow flow cytometry strongly suggested hepatosplenic \u03b3\u03b4 T-cell lymphoma and infiltration of bone marrow samples by pathological T-lymphocytes confirmed the diagnosis. Despite chemotherapy the patient died 1\u2005year after diagnosis. This is a rare disease that should be considered in the differential diagnosis of hepatosplenomegaly especially when it presents with B-symptoms and no lymph node enlargement. There is no standard therapy and the prognosis is poor.<\/jats:p>","DOI":"10.1136\/bcr-2013-009423","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T12:28:59Z","timestamp":1404995339000},"page":"bcr2013009423","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatosplenic T-cell lymphoma: a rare cause of hepatosplenomegaly"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ana Cristina","family":"Llad\u00f3","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Santo Ant\u00f3nio dos Capuchos, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luisa","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Santo Ant\u00f3nio dos Capuchos, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Henrique","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Santo Ant\u00f3nio dos Capuchos, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Farinha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de S\u00e3o Jos\u00e9, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"2025082701455873000_2014.jul10_1.bcr2013009423.1","unstructured":"Swerdlow SH Campo E Harris NL . 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