{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:02:19Z","timestamp":1781701339963,"version":"3.54.5"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Eugenol is an active, principal aromatic liquid responsible for several pharmacological activities. It is widely used in dental practice to relieve pain arising from various sources, such as pulpitis and dentinal hypersensitivity. As a primary irritant and sensitiser, it is known to cause contact urticaria as well as chronic urticaria. However, eugenol causes allergic contact dermatitis, possibly because it can react directly with proteins to form conjugate and reactive haptens. It is found that eugenol in various dental preparations-especially in the case of some zinc oxide\u2013contains preparations such as periodontal dressings and root canal cements. This can cause hypersensitivity when it comes in contact with gingiva or teeth. This article presents a case of immediate allergic contact urticaria to eugenol during dental treatment.<\/jats:p>","DOI":"10.1136\/bcr-2013-009464","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T13:23:44Z","timestamp":1379510624000},"page":"bcr2013009464","source":"Crossref","is-referenced-by-count":31,"title":["An unexpected positive hypersensitive reaction to eugenol"],"prefix":"10.1136","volume":"2013","author":[{"given":"Praveen","family":"Tammannavar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpalatha","family":"C","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrenik","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"SV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuroscience.2012.02.040","article-title":"Presynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channels","volume":"2013","author":"Inoue","year":"2012","journal-title":"Neuroscience"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0142-9612(00)00267-2","article-title":"Reactive oxygen species generation and photo-cytotoxicity of eugenol in solutions of various pH","volume":"2013","author":"Atsumi","year":"2001","journal-title":"Biomaterials"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.3","first-page":"60","article-title":"Evaluation of certain food additives and contaminants","volume":"2013","author":"FAO\/WHO Expert Committee on Food Additives","year":"1982","journal-title":"WHO Techl Rep Ser"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.bdj.4801539","article-title":"Adverse reactions associated with the use of eugenol in dentistry","volume":"2013","author":"Sarrami","year":"2002","journal-title":"Br Dent J"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.5","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1177\/00220345840630110101","article-title":"Effect of eugenol on respiration and division in human pulp, mouse fibroblasts, and liver cells in vitro","volume":"2013","author":"Hume","year":"1984","journal-title":"J Dent Res"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.6","first-page":"257","article-title":"Intravenous eugenol causes hemorrhagic lung edema in rats: proposed oxidant mechanisms","volume":"2013","author":"Wright","year":"1995","journal-title":"J Lab Clin Med"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.7","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1177\/00220345780570110901","article-title":"The effect of eugenol on oral mucous membranes","volume":"2013","author":"Kozam","year":"1978","journal-title":"J Dent Res"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.8","first-page":"381","article-title":"Eugenol-mediated superoxide generation and cytotoxicity in guinea pig neutrophils","volume":"2013","author":"Suzuki","year":"1985","journal-title":"Jpn J Pharmacol"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/ajrccm\/143.4_Pt_1.806","article-title":"Eugenol causes oxidant-mediated edema in isolated perfused rabbit lungs","volume":"2013","author":"McDonald","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.10","first-page":"513","article-title":"Allergies to dental materials","volume":"2013","author":"Wiltshire","year":"1996","journal-title":"Quintessence Int"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2591.2007.01275.x","article-title":"Root canal treatment on a patient with zinc oxide allergy: a case report","volume":"2013","author":"Karabucak","year":"2007","journal-title":"Int Endod J"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.12","doi-asserted-by":"crossref","first-page":"6953","DOI":"10.3390\/molecules17066953","article-title":"Eugenol\u2014from the remote Maluku Islands to the international market place: a review of a remarkable and versatile molecule","volume":"2013","author":"Kamatou","year":"2012","journal-title":"Molecules"},{"key":"2025042709193956000_2013.sep18_1.bcr2013009464.13","doi-asserted-by":"crossref","unstructured":"Barceloux DG . 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