{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:03:28Z","timestamp":1788581008155,"version":"build-2803163510"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is a multisystem inflammatory disease characterised by destructive synovitis and varied extra-articular involvement. Rheumatoid lung nodules are the most common pulmonary manifestations of RA. Rheumatoid nodules in mediastinal lymph nodes are extremely uncommon. We describe a male patient with long-standing RA and subcutaneous rheumatoid nodules presenting with multiple lung nodules and mediastinal lymphadenopathies. Definite histopathology of a lymph node was consistent with necrobiotic granuloma due to RA. Clinicians should be aware of rheumatoid nodules as a potential cause of mediastinal lymphadenopathies, mainly in advanced rheumatoid arthritis.<\/jats:p>","DOI":"10.1136\/bcr-2013-009516","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T07:52:45Z","timestamp":1367567565000},"page":"bcr2013009516","source":"Crossref","is-referenced-by-count":2,"title":["A rheumatoid nodule in an unusual location: mediastinal lymph node"],"prefix":"10.1136","volume":"2013","author":[{"given":"Ralph","family":"Yachoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Kreidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"2025042707481346000_2013.may02_1.bcr2013009516.1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/BOR.0b013e32835f693f","article-title":"Extra-articular rheumatoid arthritis","volume":"2013","author":"Turesson","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ccm.2010.04.003","article-title":"Pulmonary manifestations of rheumatoid arthritis","volume":"2013","author":"Antin-Ozerkis","year":"2010","journal-title":"Clin Chest Med"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0046-8177(96)90137-9","article-title":"Granuloma annulare and necrobiosis lipoidica tissue reactions as a manifestation of systemic disease","volume":"2013","author":"Magro","year":"1996","journal-title":"Hum Pathol"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00063198-200209000-00018","article-title":"The pathology of sarcoidosis","volume":"2013","author":"Gal","year":"2002","journal-title":"Curr Opin Pulm Med"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.5858\/arpa.2012-0248-SA","article-title":"Pleuropulmonary pathology in patients with rheumatic disease","volume":"2013","author":"Schneider","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/BOR.0b013e3282f798ed","article-title":"Lung disease in rheumatoid arthritis","volume":"2013","author":"Nannini","year":"2008","journal-title":"Curr Opin Rheumatol"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.7","first-page":"169","article-title":"Pleuro-pulmonary manifestations of rheumatoid polyarthritis","volume":"2013","author":"Perez","year":"1991","journal-title":"Rev Mal Respir"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1378\/chest.08-2354","article-title":"A rare cause of multiple cavitary nodules","volume":"2013","author":"Patel","year":"2009","journal-title":"Chest"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1378\/chest.96.5.1022","article-title":"Nodular pulmonary opacities in patients with rheumatoid arthritis. A diagnostic dilemma","volume":"2013","author":"Jolles","year":"1989","journal-title":"Chest"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.10","first-page":"429","article-title":"Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70","volume":"2013","author":"Orme","year":"2012","journal-title":"Biologics"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/01.rhu.0000081260.50171.bf","article-title":"Cavitary necrobiotic nodule imitating malignant lung disease in a patient without articular manifestations of rheumatoid arthritis","volume":"2013","author":"Karadag","year":"2003","journal-title":"J Clin Rheumatol"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2214\/ajr.131.2.325","article-title":"Mediastinal lymphadenopathy and undifferentiated connective tissue disease: case report and review","volume":"2013","author":"Gordonson","year":"1978","journal-title":"AJR Am J Roentgenol"},{"key":"2025042707481346000_2013.may02_1.bcr2013009516.13","doi-asserted-by":"crossref","unstructured":"Nakajima T Yasufuku K Yoshino I . 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