{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:42:54Z","timestamp":1756381374308,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 14-year-old asymptomatic girl without relevant medical history was referred to our department for heart murmur evaluation. The echocardiogram showed cardiac chambers with normal size and function. Noteworthy was the presence of an apparently fibrous tissue joining the ventricular surfaces of the aortic non-coronary and right coronary leaflets with the anterior mitral leaflet. Both valves were slightly thickened and there was a mild anterior mitral valve \u2018billowing\u2019 causing an eccentric mild-to-moderate regurgitant jet. During systole, tethering of this tissue caused the incomplete opening of both mentioned aortic leaflets, causing a turbulent flow with no significant gradient across the valve. During diastole, moderate eccentric aortic regurgitation jet was noted, probably related to incomplete coaptation at the insertion point of this anomalous tissue. We speculate that this finding may represent the remnant of some tissue during heart development that abnormally persisted in this young lady.<\/jats:p>","DOI":"10.1136\/bcr-2013-009550","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:30:54Z","timestamp":1368664254000},"page":"bcr2013009550","source":"Crossref","is-referenced-by-count":0,"title":["Aortic valve tethering: embryonic remnant of a common origin?"],"prefix":"10.1136","volume":"2013","author":[{"given":"Luis","family":"Alvarez-Acosta","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estanislao","family":"Soriano-Vela","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Facenda-Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Farrais-Villalba","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"2025082804013006000_2013.may15_1.bcr2013009550.1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/dvdy.21725","article-title":"Origin and fate of cardiac mesenchyme","volume":"2013","author":"Snarr","year":"2008","journal-title":"Dev dyn"},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCRESAHA.109.201566","article-title":"Heart valve development: regulatory networks in development and disease","volume":"2013","author":"Combs","year":"2009","journal-title":"Circ Res"},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.3","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1161\/CIRCULATIONAHA.108.805911","article-title":"Evolving concepts of cardiac valve dynamics","volume":"2013","author":"Schoen","year":"2008","journal-title":"Circulation"},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.4","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.RES.0000224114.65109.4e","article-title":"Extracellular matrix remodeling and organization in developing and diseased aortic valves","volume":"2013","author":"Hinton","year":"2006","journal-title":"Circ Res"},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.5","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/heart.89.7.806","article-title":"Development of the heart: formation of the cardiac chambers and arterial trunks","volume":"2013","author":"Moorman","year":"2003","journal-title":"Heart"},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.6","unstructured":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: Mitral and tricuspid regurgitation (native valve disease). Patrizio Lancellotti (Chair), Luis Moura, Luc A Pierard, Eustachio Agricola, Bogdan A Popescu, Christophe Tribouilloy, Andreas Hagendorff, Jean-Luc Monin, Luigi Badano, and Jose L Zamorano on behalf of the European Association of Echocardiography."},{"key":"2025082804013006000_2013.may15_1.bcr2013009550.7","unstructured":"Guidelines on the management of valvular heart disease (version 2012) The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) (1) European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: Mitral and tricuspid regurgitation (native valve disease). Patrizio Lancellotti (Chair), Luis Moura, Luc A Pierard, Eustachio Agricola, Bogdan A Popescu, Christophe Tribouilloy, Andreas Hagendorff, Jean-Luc Monin, Luigi Badano and Jose L Zamorano on behalf of the European Association of Echocardiography."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:01:41Z","timestamp":1756378901000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":7,"alternative-id":["10.1136\/bcr-2013-009550"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009550","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}