{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:10:02Z","timestamp":1756372202131,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The diagnosis\u2018 Aggressive Periodontitis\u2019 (AgP), defined by the International workshop for a classification of periodontal diseases and conditions in 1999, refers to the multifactorial, severe and rapidly progressive form of periodontitis, which primarily\u2014but not exclusively\u2014affects younger patients. Direct and indirect bacterial effects influencing the host immune response play a significant part in the aetiology of AgP comparable with chronic periodontitis. In addition to various virulence factors of specific periodontal pathogens, a genetic predisposition influences the outbreak and progression of the disease. This report describes the disciplinary treatment of AgP patient with progressing full-mouth bone resorption.<\/jats:p>","DOI":"10.1136\/bcr-2013-009601","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T08:19:49Z","timestamp":1372407589000},"page":"bcr2013009601","source":"Crossref","is-referenced-by-count":0,"title":["A clinically hidden but severely destructive entity"],"prefix":"10.1136","volume":"2013","author":[{"given":"Khushboo","family":"Rastogi","sequence":"first","affiliation":[{"name":"Periodontics & Implantology, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Orthodontics & Dentofacial Orthopedics, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajarshi","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics & Dentofacial Orthopedics, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.1","first-page":"334","article-title":"Aggressive periodontitis","volume":"2013","author":"Noack","year":"2004","journal-title":"Perio"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.2","first-page":"133","article-title":"Determinants of host susceptibility in aggressive periodontitis","volume":"2013","author":"Meng","year":"2000","journal-title":"Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1600-051X.2009.01391.x","article-title":"The clinical course of chronic periodontitis: V. Predictive factors in periodontal disease","volume":"2013","author":"Sch\u00e4tzle","year":"2009","journal-title":"J Clin Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.4","first-page":"168","article-title":"Juvenile periodontitis","volume":"2013","author":"Genco","year":"1986","journal-title":"Int Dent J"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.5","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1128\/JCM.00653-07","article-title":"Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescents","volume":"2013","author":"Fine","year":"2007","journal-title":"J Clin Microbiol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1902\/jop.2000.71.6.912","article-title":"Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis","volume":"2013","author":"Haraszthy","year":"2000","journal-title":"J Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.7","first-page":"3058","article-title":"Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis","volume":"2013","author":"Di Rienzo","year":"1986","journal-title":"Infect Immun"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1600-0765.1984.tb01321.x","article-title":"Abnormal leukocyte motility in patients with early-onset periodontitis","volume":"2013","author":"Page","year":"1984","journal-title":"J Peridontal Res"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1128\/iai.47.1.169-175.1985","article-title":"Defective neutrophil and monocyte motility in patients with early onset periodontitis","volume":"2013","author":"Page","year":"1985","journal-title":"Infect Immun"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0765.1979.tb00213.x","article-title":"Impaired neutrophil chemotaxis in patients with juvenile and rapidly progressing periodontitis","volume":"2013","author":"Lavine","year":"1979","journal-title":"J Peridontal Res"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.11","first-page":"202","article-title":"Genetic factors in the pathogenesis of periodontitis","volume":"2013","author":"Hart","year":"2000","journal-title":"Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.12","first-page":"91","article-title":"The genetic basis of periodontitis","volume":"2013","author":"Kinane","year":"2000","journal-title":"Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0030-4220(76)90029-3","article-title":"Periodontosis: a phenotypic and genetic analysis","volume":"2013","author":"Melnick","year":"1976","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1902\/jop.1985.56.10.602","article-title":"Clinical and laboratory studies of a family with a high prevalence of juvenile periodontitis","volume":"2013","author":"Page","year":"1985","journal-title":"J Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.15","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1902\/jop.2010.090643","article-title":"Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects","volume":"2013","author":"Rescala","year":"2010","journal-title":"J Periodontol"},{"key":"2025082801461808000_2013.jun27_1.bcr2013009601.16","first-page":"154","article-title":"Response of chronic and aggressive periodontitis to treatment","volume":"2013","author":"Deas","year":"2000","journal-title":"Periodontol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:46:25Z","timestamp":1756370785000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":16,"alternative-id":["10.1136\/bcr-2013-009601"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009601","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}