{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:53:00Z","timestamp":1772772780746,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disorder resulting from a highly stimulated immune response with uncontrolled accumulation of lymphocytes and macrophages in multiple organs. Both the inherited and acquired forms of this disease exist; the latter can sometimes occur secondary to different malignancies. In this report, we present a middle-aged Hispanic man who presented with features of septic shock during the course of chemotherapy for squamous cell carcinoma of the neck. Despite aggressive treatment for septic shock, he rapidly deteriorated and died after 30\u2005h of admission. Autopsy findings confirmed a diagnosis of HLH. HLH should be recognised as a serious adverse event during chemotherapy for different malignancies including squamous cell carcinoma of the neck.<\/jats:p>","DOI":"10.1136\/bcr-2013-009651","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T12:19:49Z","timestamp":1372421989000},"page":"bcr2013009651","source":"Crossref","is-referenced-by-count":8,"title":["Haemophagocytic lymphohistiocytosis mimicking septic shock after the initiation of chemotherapy for squamous cell sarcinoma of the neck"],"prefix":"10.1136","volume":"2013","author":[{"given":"Madan Raj","family":"Aryal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madan","family":"Badal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smith","family":"Giri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shambhu","family":"Aryal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/rmv.638","article-title":"Viral infections associated with haemophagocytic syndrome","volume":"2013","author":"Maakaroun","year":"2010","journal-title":"Rev Med Virol"},{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/QAD.0b013e328339e55b","article-title":"Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis","volume":"2013","author":"Fardet","year":"2010","journal-title":"AIDS"},{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000312628","article-title":"Macrophage activation syndrome in autoimmune disease","volume":"2013","author":"Deane","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.4","first-page":"1064","article-title":"[Significance of hemophagocytosis in diagnosis of hemophagocytic lymphohistiocytosis]","volume":"2013","author":"Wang","year":"2009","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jbspin.2011.10.015","article-title":"Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment","volume":"2013","author":"Larroche","year":"2012","journal-title":"Joint Bone Spine"},{"key":"2025042708270144000_2013.jun27_1.bcr2013009651.6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C","article-title":"Contemporary classification of histiocytic disorders. 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