{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:55Z","timestamp":1787016955473,"version":"build-2736575974"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Mucus plugging plays a vital role in the pathophysiology of fatal and near fatal asthma as demonstrated in various postmortem studies. There is a paucity of published literature on how to manage mucus plugging in adult patients with refractory asthma exacerbation not responding to conventional therapies as compared with its paediatric cohort. We describe a dramatic improvement with the use of rhDNase, following bronchoalveolar lavage in an intubated adult female patient, with status asthmaticus refractory to conventional treatment.<\/jats:p>","DOI":"10.1136\/bcr-2013-009661","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T14:54:48Z","timestamp":1372431288000},"page":"bcr2013009661","source":"Crossref","is-referenced-by-count":5,"title":["Nebulised DNase post-therapeutic bronchoalveolar lavage in near fatal asthma exacerbation in an adult patient refractory to conventional treatment"],"prefix":"10.1136","volume":"2013","author":[{"given":"A C L","family":"Chia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Menzies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"McKeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0002-9343(03)00241-9","article-title":"Characterization of airway plugging in fatal asthma","volume":"2013","author":"Kuyper","year":"2003","journal-title":"Am J Med"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.2","unstructured":"BTS\/SIGN Asthma Guidelines 2012."},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1378\/chest.125.3.1081","article-title":"Acute asthma in adults\u2014a review","volume":"2013","author":"Rodrigo","year":"2004","journal-title":"Chest"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.4","first-page":"95","article-title":"Management of life-threatening asthma in adults","volume":"2013","author":"Stanley","year":"2008","journal-title":"Oxford JMed BJA: CEACCP"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/MCP.0b013e3282f1982d","article-title":"Near-fatal asthma: recognition and management","volume":"2013","author":"Restrepo","year":"2008","journal-title":"Curr Opin in Pulm Med"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.6","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1164\/ajrccm\/147.5.1132","article-title":"Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects","volume":"2013","author":"Fahy","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.resuscitation.2006.11.006","article-title":"Nebulised DNAse in life threatening asthma","volume":"2013","author":"Hull","year":"2007","journal-title":"Resuscitation"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00003246-200002000-00045","article-title":"Resolution of mucus plugging and atelectasis after intratracheal rhDNase therapy in a mechanically ventilated child with refractory status asthmaticus","volume":"2013","author":"Durward","year":"2000","journal-title":"Crit Care Med"},{"issue":"Suppl 1","key":"2025042708245188000_2013.jun25_1.bcr2013009661.9","doi-asserted-by":"crossref","first-page":"P185","DOI":"10.1186\/cc9605","article-title":"Safety and efficacy of intratracheal DNase with physiotherapy in severe status asthmaticus","volume":"2013","author":"Nyman","year":"2011","journal-title":"Crit Care"},{"key":"2025042708245188000_2013.jun25_1.bcr2013009661.10","first-page":"141","article-title":"Recombinant human deoxyribonuclease for the treatment of acute asthma in children","volume":"2013","author":"Boogaard","year":"2008","journal-title":"Thorax"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T11:25:02Z","timestamp":1745753102000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":10,"alternative-id":["10.1136\/bcr-2013-009661"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009661","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}