{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:36Z","timestamp":1787017056354,"version":"build-2736575974"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Good\u2019s syndrome (GS) is an immunodeficiency characterised by thymoma, hypogammaglobulinemia and impaired T-cell function. The clinical symptoms are recurrent or chronic infections from common or opportunistic pathogens and diarrhoea. Encephalitis is rare, mostly associated to cytomegalovirus. We present a 65-year-old woman who developed blindness, motor deficits and cognitive changes over a 4-month period. MRI of the brain showed symmetric subcortical white matter changes in the occipital lobes, first thought to correspond to posterior reversible encephalopathy syndrome. A thymoma was found and operated. The patient had no B cells, low immunoglobulins and an inverted CD4\/CD8 ratio. GS was diagnosed. In the cerbrospinal fluid &gt;1\u2005 million JC virus copies\/mL were found and a repeat MRI now showed a picture compatible with progressive multifocal leucoencephalopathy (PML). Her disease had a fatal outcome. The present case is the second reported association between GS and PML.<\/jats:p>","DOI":"10.1136\/bcr-2013-009763","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T08:01:03Z","timestamp":1375084863000},"page":"bcr2013009763","source":"Crossref","is-referenced-by-count":11,"title":["Progressive multifocal leukoencephalopathy in a patient with Good\u2019s syndrome"],"prefix":"10.1136","volume":"2013","author":[{"given":"Olafur","family":"Sveinsson","sequence":"first","affiliation":[{"name":"Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Matell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Herrman","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"2025082723052951000_2013.jul29_1.bcr2013009763.1","first-page":"1","article-title":"Agammaglobulinemia: a provocative experiment of nature","volume":"2013","author":"Good","year":"1954","journal-title":"Bull Univ Minn"},{"key":"2025082723052951000_2013.jul29_1.bcr2013009763.2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.clim.2010.01.006","article-title":"Good's syndrome remains a mystery after 55 years: a systematic review of the scientific evidence","volume":"2013","author":"Kelesidis","year":"2010","journal-title":"Clin Immunol"},{"key":"2025082723052951000_2013.jul29_1.bcr2013009763.3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00005792-200103000-00005","article-title":"Infections in patients with immunodeficiency with thymoma (Good's syndrome). Report of 5 cases and review of the literature","volume":"2013","author":"Tarr","year":"2001","journal-title":"Medicine (Baltimore)"},{"key":"2025082723052951000_2013.jul29_1.bcr2013009763.4","doi-asserted-by":"crossref","first-page":"e444","DOI":"10.1016\/j.ijid.2009.06.005","article-title":"Progressive multifocal leukoencephalopathy in a patient with Good's syndrome","volume":"2013","author":"Squintani","year":"2010","journal-title":"Int J Infect Dis"},{"key":"2025082723052951000_2013.jul29_1.bcr2013009763.5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.clineuro.2012.06.018","article-title":"Common and uncommon imaging findings in progressive multifocal leukoencephalopathy (PML) with differential diagnostic considerations","volume":"2013","author":"Horger","year":"2012","journal-title":"Clin Neurol Neurosurg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:05:40Z","timestamp":1756361140000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,29]]},"references-count":5,"alternative-id":["10.1136\/bcr-2013-009763"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009763","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,29]]}}}