{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:13:04Z","timestamp":1780917184765,"version":"3.54.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Melorheostosis is a very rare sclerosing bone disorder that involves frequently one limb. It may be asymptomatic, but pain and limb deformity may occur and can be very debilitating. Different reports have indicated efficacy of bisphosphonates (pamidronate and etidronate) on symptoms. We report an adult patient with a very painful melorheostosis, who \u00a0improved after treatment with zoledronate, either on symptoms or on bone scans.<\/jats:p>","DOI":"10.1136\/bcr-2013-009820","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T11:59:58Z","timestamp":1372420798000},"page":"bcr2013009820","source":"Crossref","is-referenced-by-count":27,"title":["Successful treatment of pain in melorheostosis with zoledronate, with improvement on bone scintigraphy"],"prefix":"10.1136","volume":"2013","author":[{"given":"Samy","family":"Slimani","sequence":"first","affiliation":[{"name":"Department of Medicine, Hadj Lakhdar University, Batna, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adlen","family":"Nezzar","sequence":"additional","affiliation":[{"name":"Nuclear Imaging Center, Batna, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hachemi","family":"Makhloufi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hadj Lakhdar University, Batna, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2106\/00004623-196850070-00001","article-title":"Melorheostosis: a report of the clinical, roentgenographic, and pathological findings in fourteen cases","volume":"2013","author":"Campbell","year":"1968","journal-title":"J Bone Joint Surg Am"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1148\/114.3.577","article-title":"Melorheostosis with linear sclerodermatous skin changes","volume":"2013","author":"Soffa","year":"1975","journal-title":"Radiology"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.3","first-page":"193","article-title":"Melorheostosis in adults. A propos of 2 cases of them treated with diphosphonate (EHDP)","volume":"2013","author":"Bied","year":"1976","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.4","first-page":"856","article-title":"Un cas de m\u00e9lorheostose trait\u00e9 par disphosphonate","volume":"2013","author":"Mora","year":"1986","journal-title":"Acta Orthop Belg"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.5","first-page":"709","article-title":"Atypical form of active melorheostosis and its treatment with bisphosphonate","volume":"2013","author":"Donath","year":"2002","journal-title":"Skeletal Radiol"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.6","first-page":"204","article-title":"R\u00e9v\u00e9lation atypique d'une melorheostose am\u00e9lior\u00e9e par du pamidronate","volume":"2013","author":"Saadallaoui Ben Hamida","year":"2009","journal-title":"Tunisie Medicale"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jbspin.2007.07.018","article-title":"Melorheostosis and FGF-23: is there a relationship?","volume":"2013","author":"Kerkeni","year":"2008","journal-title":"Joint Bone Spine"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00349329","article-title":"Melorheostosis and the sclerotomes: a radiological correlation","volume":"2013","author":"Murray","year":"1979","journal-title":"Skeletal Radiol"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.9","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/ng1453","article-title":"Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis","volume":"2013","author":"Hellemans","year":"2004","journal-title":"Nat Genet"},{"key":"2025082804381005000_2013.jun21_2.bcr2013009820.10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.knee.2006.05.006","article-title":"Soft tissue knee contracture of the knee due to melorheostosis, treated by total knee arthroplasty","volume":"2013","author":"Moulder","year":"2006","journal-title":"Knee"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:38:18Z","timestamp":1756381098000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":10,"alternative-id":["10.1136\/bcr-2013-009820"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009820","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}