{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:18:02Z","timestamp":1780089482995,"version":"3.54.0"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Type 1 diabetes mellitus (T1DM) is a common cause of end-stage renal disease (ESRD). Various factors contribute to wide fluctuations in blood glucose levels and exogenous insulin requirement in such patients even after renal transplantation (RT). Simultaneous pancreas\u2013kidney transplantation is one of the therapies for these patients. Stem cell (SC) therapy for T1DM and for minimisation of immunosuppression after RT has shown encouraging results. We report a 30-year-old-man with T1DM since 15\u2005years and ESRD since 2\u2005years, who underwent living donor RT \u00a0and co-infusion of in vitro generated insulin-making cells differentiated from donor adipose tissue derived mesenchymal stem cells \u00a0and bone marrow -derived haematopoietic SC \u00a0into subcutaneous tissue, portal and thymic circulation under non-myeloablative conditioning. Over follow-up of 13\u2005months he has stable graft function with serum creatinine, 1.2\u2005mg\/dl, zero rejection and glycosylated haemoglobin level of 6.1% on calcineurin-inhibitor based therapy.<\/jats:p>","DOI":"10.1136\/bcr-2013-009901","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T01:54:51Z","timestamp":1369360491000},"page":"bcr2013009901","source":"Crossref","is-referenced-by-count":8,"title":["Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: a novel therapy for type 1 diabetes mellitus with end-stage renal disease"],"prefix":"10.1136","volume":"2013","author":[{"given":"Shruti D","family":"Dave","sequence":"first","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna V","family":"Vanikar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hargovind L","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)-Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"2025082702060387000_2013.may23_1.bcr2013009901.1","doi-asserted-by":"crossref","unstructured":"Vanikar AV Dave SD Thakkar UG . Co-transplantation of adipose tissue-derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: A novel therapy for insulin-dependent diabetes mellitus. Stem Cells Int 2010; Article ID 582382: 5 pages.","DOI":"10.4061\/2010\/582382"},{"key":"2025082702060387000_2013.may23_1.bcr2013009901.2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2337\/diabetes.50.7.1546","article-title":"Indirect allorecognition in acquired thymic tolerance induction of donor-specific permanent acceptance of rat islets by adoptive transfer of allopeptide-pulse host myeloid and thymic dendritic cells","volume":"2013","author":"Oluwole","year":"2001","journal-title":"Diabetes"},{"key":"2025082702060387000_2013.may23_1.bcr2013009901.3","first-page":"510","article-title":"Diabetic nephropathy: etiologic and therapeutic considerations","volume":"2013 2013","author":"DeFronzo","year":"1995","journal-title":"Diabetes Rev"},{"key":"2025082702060387000_2013.may23_1.bcr2013009901.4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/ajkd.2002.30549","article-title":"Long-term glycemic control measurements in diabetic patients receiving hemodialysis","volume":"2013","author":"Joy","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"2025082702060387000_2013.may23_1.bcr2013009901.5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1046\/j.1464-5491.2003.01025.x","article-title":"Decreased insulin requirement in relation to GFR in nephropathic type 1 and insulin-treated type 2 diabetic patients","volume":"2013","author":"Biesenbach","year":"2003","journal-title":"Diabet Med"},{"key":"2025082702060387000_2013.may23_1.bcr2013009901.6","first-page":"649","article-title":"Managing diabetes in hemodialysis patients: observations and recommendations","volume":"2013","author":"Kumarpal","year":"2009","journal-title":"Cleve Clin J Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:06:16Z","timestamp":1756285576000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":6,"alternative-id":["10.1136\/bcr-2013-009901"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009901","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]}}}