{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:19:12Z","timestamp":1784715552558,"version":"3.55.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Kyrle's disease (KD) is a dermatosis which was first described by Kyrle as \u201chyperkeratosis follicularis et parafollicularis in cutem penetrans\u201d in 1916. Perforating dermatoses are a heterogeneous disorder group characterised by transepithelial elimination. KD has been seen in association with multiple disorders, including diabetes mellitus, renal and liver diseases, congestive heart failure, hyperlipidaemia, infective diseases and abnormal metabolism of vitamin A. This case report presents two patients with KD with associated systemic disease.<\/jats:p>","DOI":"10.1136\/bcr-2013-009905","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T14:59:23Z","timestamp":1389797963000},"page":"bcr2013009905","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Kyrle's disease"],"prefix":"10.1136","volume":"2014","author":[{"given":"Arzu","family":"Ataseven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perihan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iknur","family":"Kucukosmanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcan Saylam","family":"Kurtipek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01826081"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.41654"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.3","first-page":"222","article-title":"Kyrle's disease: a cutaneous marker of renal disorder","volume":"62","author":"Joseph","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.4","doi-asserted-by":"publisher","DOI":"10.1159\/000333005"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01988.x"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.6","doi-asserted-by":"publisher","DOI":"10.5152\/eajm.2012.11"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.7","first-page":"83","article-title":"Kyrle's disease (case report)","volume":"2","author":"Acay","year":"1992","journal-title":"Turkiye Klinikleri J Dermatol"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.8","doi-asserted-by":"crossref","first-page":"679619","DOI":"10.5402\/2012\/679619","article-title":"Cutaneous manifestations in patients with chronic kidney disease on maintenance hemodialysis","volume":"2012","author":"Kolla","year":"2012","journal-title":"ISRN Dermatol"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.9","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.97127"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.006"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.11","first-page":"156","article-title":"Kyrle's disease and vitamin D resistant rickets in chronic renal failure (le)","volume":"64","author":"Shah","year":"1998","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025042702130579000_2014.jan15_2.bcr2013009905.12","unstructured":"Odom RB James WD Berger TG . Andrews\u2019 diseases of the skin in diseases of the skin appendages. 9th edn. 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