{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:32:20Z","timestamp":1790764340075,"version":"4.1.0"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Superficial siderosis is caused by recurrent haemorrhage in the subarachnoid space leading to haemosiderin deposition. It typically causes the triad of ataxia, deafness and myelopathy. We report a patient who developed superficial siderosis following neurosurgery for syringomyelia and who had an improvement in his hearing and mobility following treatment with a new iron chelation therapy that can penetrate the blood\u2013brain barrier. It provides an intriguing insight into a therapy that could potentially modify the course of this rare neurodegenerative disorder. Further studies are required to assess the clinical efficacy of deferiprone in superficial siderosis.<\/jats:p>","DOI":"10.1136\/bcr-2013-009916","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T07:04:30Z","timestamp":1373439870000},"page":"bcr2013009916","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of superficial siderosis with iron chelation therapy"],"prefix":"10.1136","volume":"2013","author":[{"given":"Gemma","family":"Cummins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Crundwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baguley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Lennox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/brain\/118.4.1051","article-title":"Superficial siderosis of the central nervous system","volume":"2013","author":"Fearnley","year":"1995","journal-title":"Brain"},{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.2","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1136\/jnnp.74.9.1326","article-title":"Superficial siderosis of the central nervous system many years after neurosurgical procedures","volume":"2013","author":"McCarron","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1212\/WNL.52.1.163","article-title":"Superficial siderosis of the central nervous system: a late complication of cerebellar tumors","volume":"2013","author":"Anderson","year":"1999","journal-title":"Neurology"},{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3171\/2013.1.SPINE12649","article-title":"Dural closure for the treatment of superficial siderosis","volume":"2013","author":"Egawa","year":"2013","journal-title":"J Neurosurg Spine"},{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0300-483X(95)03301-U","article-title":"The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl- and 1-[ethan-1\u2032ol]-2-methyl-3-hydroxypyridin-4-one in the rat","volume":"2013","author":"Freedenburg","year":"1996","journal-title":"Toxicology"},{"key":"2025042708322763000_2013.jul08_2.bcr2013009916.6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/STROKEAHA.111.628032","article-title":"Pilot safety trial of deferiprone in 10 subjects with superficial siderosis","volume":"2013","author":"Levy","year":"2012","journal-title":"Stroke"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-009916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:32:35Z","timestamp":1745767955000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-009916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":6,"alternative-id":["10.1136\/bcr-2013-009916"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-009916","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}