{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:37:58Z","timestamp":1787495878193,"version":"build-2736575974"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Prosthetic heart valve thrombosis is a rare but serious complication. Surgery is the first-line therapy in symptomatic obstructive mechanical valve thrombosis, thrombolytic therapy has been used as an alternative to surgical treatment. In this case report we described a 47-year-old woman who had undergone coronary artery bypass graft and mitral valve replacement operation 9\u2005months ago. A thrombus was detected on the prosthetic mitral valve with high transmitral gradient by transoesophageal echocardiography. Tissue plasminogen activator treatment was administered successfully. The gradient was improved on prosthetic mitral valve and embolic complications or bleeding were not occurred.<\/jats:p>","DOI":"10.1136\/bcr-2013-009917","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T01:33:45Z","timestamp":1370655225000},"page":"bcr2013009917","source":"Crossref","is-referenced-by-count":6,"title":["Successful thrombolytic treatment of prosthetic mitral valve thrombosis"],"prefix":"10.1136","volume":"2013","author":[{"given":"Emine","family":"Gazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Altun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Temiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucel","family":"Colkesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,6,7]]},"reference":[{"key":"2025042708133185000_2013.jun07_1.bcr2013009917.1","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/eurheartj\/ehm405","article-title":"Improving the quality of anticoagulant therapy in patients with mechanical heart valves: what are we waiting for?","volume":"2013","author":"Herijgers","year":"2007","journal-title":"Eur Heart J"},{"key":"2025042708133185000_2013.jun07_1.bcr2013009917.2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.acvd.2009.01.007","article-title":"Management of prosthetic heart valve obstruction: fibrinolysis versus surgery. 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