{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:13:51Z","timestamp":1789370031311,"version":"build-2803163510"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 39-year-old man (a lifetime non-smoker) presented with a locked left jaw and leg myoclonus. Clinical and electromyographic findings were in keeping with progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome. A thoracic CT scan demonstrated a 19\u2005mm right hilar nodule, which was proven to be small cell lung cancer on bronchoscopic biopsy. Serological evaluation of the patient's plasma revealed antibodies against glycine receptors (serology negative for anti-GAD, anti-Yo, anti-Hu, anti-Ri, antiamphiphysin, anti-Ma2\/Ta, anti-CRMP5 and anti-NMDA receptor). After his cancer was treated with chemotherapy and intravenous immunoglobulins (IVIg), neurological symptoms resolved but returned several months later without any evidence of cancer recurrence. Symptoms were refractory to corticosteroids and IVIg therapy. Rituximab was then initiated, which led to a dramatic and sustained resolution of symptoms. To our knowledge, this is the first case of PERM related to antiglycine receptor antibodies from paraneoplastic syndrome, which resolved with rituximab.<\/jats:p>","DOI":"10.1136\/bcr-2013-010027","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T11:42:19Z","timestamp":1372419739000},"page":"bcr2013010027","source":"Crossref","is-referenced-by-count":30,"title":["Antiglycine receptor antibody and encephalomyelitis with rigidity and myoclonus (PERM) related to small cell lung cancer"],"prefix":"10.1136","volume":"2013","author":[{"given":"Robert","family":"Kyskan","sequence":"first","affiliation":[{"name":"Department of Medicine and Department of Pathology and Laboratory Medicine, University of British Columbia and St Paul's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Pathology and Laboratory Medicine, University of British Columbia and St Paul's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mattman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Pathology and Laboratory Medicine, University of British Columbia and St Paul's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Sin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Pathology and Laboratory Medicine, University of British Columbia and St Paul's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1172-2-22","article-title":"Paraneoplastic neurological syndromes","volume":"2013","author":"Honnorat","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/jnnp.54.9.764","article-title":"Neurological paraneoplastic syndromes in patients with small cell lung cancer. A prospective survey of 150 patients","volume":"2013","author":"Elrington","year":"1991","journal-title":"J Neurol, Neurosurg Psychiatry"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1590\/S0004-282X2004000300033","article-title":"Progressive encephalomyelitis with rigidity: a paraneoplastic presentation of oat cell carcinoma of the lung","volume":"2013","author":"Spitz","year":"2004","journal-title":"Arq Neuropsiquiatr"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1474-4422(11)70096-5","article-title":"Autoantibodies associated with diseases of the CNS: new developments and future challenges","volume":"2013","author":"Vincent","year":"2011","journal-title":"Lancet Neurol"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00415-005-0882-0","article-title":"An uncontrolled trial of rituximab for antibody associated paraneoplastic neurological syndromes","volume":"2013","author":"Shams'ili","year":"2006","journal-title":"J Neurol"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s11940-012-0213-6","article-title":"Paraneoplastic syndromes of the neuromuscular junction: therapeutic options in myasthenia gravis, Lambert-Eaton myasthenic syndrome and neuromyotonia","volume":"2013","author":"van Sonderen","year":"2013","journal-title":"Curr Treat Options Neurol"},{"key":"2025082707533276000_2013.jun21_1.bcr2013010027.7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/jnnp.2004.051144","article-title":"Treatment of stiff person syndrome with rituximab","volume":"2013","author":"Baker","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:53:37Z","timestamp":1756306417000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,21]]},"references-count":7,"alternative-id":["10.1136\/bcr-2013-010027"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010027","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,21]]}}}