{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:40:09Z","timestamp":1745768409834,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Lymphatic malformations are a subset of congenital vascular malformations, and are caused by a defect in lymphatic development during embryogenesis. When lymphatic mesoderm development is prematurely arrested, it retains it proliferative potential. Stimulus in the future can cause the lesion to proliferate locally without coordination or regulation, resulting in the rare condition known as massive localised lymphoedema (MLL). We present a case report of MLL, a rare and ill-defined soft tissue mass reported in the morbidly obese, with reference to the existing literature.<\/jats:p>","DOI":"10.1136\/bcr-2013-010060","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T14:52:54Z","timestamp":1371048774000},"page":"bcr2013010060","source":"Crossref","is-referenced-by-count":1,"title":["Massive localised lymphoedema: a rare vascular malformation"],"prefix":"10.1136","volume":"2013","author":[{"given":"K J","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M N","family":"Al-Sakkal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Alsafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/026835550702200604","article-title":"Terminology and classification of congenital vascular malformations","volume":"2013","author":"Lee","year":"2007","journal-title":"Phlebology"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/00000478-199810000-00013","article-title":"Massive localized lymphedema in the morbidly obese: a histalogically distinct reactive lesion simulating liposarcoma","volume":"2013","author":"Farshid","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.3","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/jcp.2009.066555","article-title":"Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature","volume":"2013","author":"Manduch","year":"2009","journal-title":"J Clin Pathol"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1445-2197.2006.03984.x","article-title":"Massive localized lymphoedema of the thigh","volume":"2013","author":"McCrystal","year":"2007","journal-title":"ANZ J Surg"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.5","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1097\/00006534-200012000-00054","article-title":"Massive localized lymphedema of suprapubic origin","volume":"2013","author":"Barr","year":"2000","journal-title":"Plast Reconstr Surg"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.6","first-page":"222A","article-title":"Massive localised lyphedema of the male external genitalia: a clinicopathologic study of 7 cases","volume":"2013","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/SAP.0b013e318211910e","article-title":"Massive localized lymphedema: review of an emerging problem and report of a complex case in the mons pubis","volume":"2013","author":"Brewer","year":"2012","journal-title":"Ann Plast Surg"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/PGP.0b013e31816017a7","article-title":"Massive vulval edema secondary to obesity and immobilization: a potential mimic of aggressive angiomyxoma","volume":"2013","author":"McCluggage","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1600-0560.2011.01703.x","article-title":"Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature","volume":"2013","author":"Shon","year":"2011","journal-title":"J Cutan Pathol"},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.10","unstructured":"Fisher C . Diagnostic pathology . In: Soft Tissue Tumors . Amirsys: 2010."},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.11","unstructured":"Weiss SW Goldblum JR Folpe AL . Enzinger and Weiss's soft tissue tumors. Elsevier, 2007."},{"key":"2025042708171296000_2013.jun12_1.bcr2013010060.12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00547-005-2009-y","article-title":"Consensus on controversial issues in contemporary diagnosis and management of congenital vascular malformation: Seoul communication","volume":"2013","author":"Lee","year":"2004","journal-title":"Int J Angiol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:17:21Z","timestamp":1745767041000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,12]]},"references-count":12,"alternative-id":["10.1136\/bcr-2013-010060"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010060","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,6,12]]}}}