{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:27:57Z","timestamp":1757701677411,"version":"3.40.4"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Cryoglobulinaemic vasculitis is characterised by immunoglobulin deposition at low temperatures. The most common manifestations are cutaneous involvement, arthralgias, Raynaud's phenomenon, peripheral neuropathy and renal disease. Myopathy is unusual and only a few cases have been reported. Here, we present a 31-year-old woman who developed progressive muscle weakness involving upper and lower extremities, dysphagia, paraesthesias and palpable purpura. Diagnostic studies revealed elevated creatine kinase, diffuse myopathic and sensorimotor axonal neuropathy on electromyography and nerve conduction studies, and inflammatory myopathy on muscle biospsy. Cryoglobulin levels were elevated on two occasions. She responded favourably to cyclophosphamide and high-dose corticosteroids. Cyclophosphamide was continued for 1\u2005year followed by methotrexate. Prednisone was gradually tapered and discontinued 1\u2005year later. She remained in clinical remission after 4\u2005years of follow-up. This case suggests that cryoglobulinaemia should be considered in the differential diagnosis of a patient presenting with inflammatory myopathy.<\/jats:p>","DOI":"10.1136\/bcr-2013-010117","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T04:53:39Z","timestamp":1370321619000},"page":"bcr2013010117","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory myopathy as the initial presentation of cryoglobulinaemic vasculitis"],"prefix":"10.1136","volume":"2013","author":[{"given":"Noelia","family":"Rodr\u00edguez-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerania","family":"Rodr\u00edguez-Navedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne M","family":"Font","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M","family":"Vil\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/BOR.0b013e32835b15f7","article-title":"Cryoglobulinemia vasculitis: an update","volume":"2013","author":"Terrier","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11864-000-0055-4","article-title":"Symptomatic cryoglobulinemia","volume":"2013","author":"Dispenzieri","year":"2000","journal-title":"Curr Treat Options Oncol"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mayocp.2012.10.017","article-title":"Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations","volume":"2013","author":"Ernste","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.4","first-page":"468","article-title":"Interstitial lung disease and cryoglobulinemia in polymyositis","volume":"2013","author":"Lambie","year":"1991","journal-title":"J Rheumatol"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/jnnp.56.3.317","article-title":"Polymyositis with plasma cell infiltrate in essential mixed cryoglobulinemia","volume":"2013","author":"Voll","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.6","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1136\/jnnp.2004.057620","article-title":"Clinical spectrum of cryoglobulinemc neuropathy","volume":"2013","author":"Gemignani","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042708090942000_2013.jun03_1.bcr2013010117.7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/jnnp.55.2.116","article-title":"Peripheral neuropathy in essential mixed cryoglobulinemia","volume":"2013","author":"Gemignani","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:09:19Z","timestamp":1745766559000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":7,"alternative-id":["10.1136\/bcr-2013-010117"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010117","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,6,3]]}}}