{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:47:55Z","timestamp":1757699275328,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Vitamin B<jats:sub>12<\/jats:sub>deficiency is a well recognised cause of macrocytic anaemia and bone marrow failure. Bone marrow aspiration\/biopsy is infrequently indicated for the diagnosis in this setting. However, if a bone marrow aspiration\/biopsy is performed, it is important to recognise that it may show dysplastic changes mimicking myelodysplastic syndrome (MDS) or acute leukaemia. We report a case of a 66-year-old non-vegetarian man presenting with generalised weakness for 1\u2005month and misdiagnosed on bone marrow biopsy as MDS. However, laboratory investigations revealed severe deficiency of vitamin B<jats:sub>12<\/jats:sub>. Four weeks after starting vitamin B<jats:sub>12<\/jats:sub>replacement the patient's complete blood counts reverted to normal.<\/jats:p>","DOI":"10.1136\/bcr-2013-010200","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T06:13:24Z","timestamp":1373350404000},"page":"bcr2013010200","source":"Crossref","is-referenced-by-count":12,"title":["What should I know before ordering a bone marrow aspiration\/biopsy in patients with vitamin B<sub>12<\/sub>deficiency?"],"prefix":"10.1136","volume":"2013","author":[{"given":"Jaskirat","family":"Randhawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L","family":"Ondrejka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebouh","family":"Setrakian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harris","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,8]]},"reference":[{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Vitamin B12 deficiency","volume":"2013","author":"Stabler","year":"2013","journal-title":"N Engl J Med"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJMicm063586","article-title":"A medical mystery\u2014a 71-year-old man with pancytopenia","volume":"2013","author":"Braza","year":"2008","journal-title":"N Engl J Med"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00043426-199605000-00013","article-title":"Transient 7q- in association with megaloblastic anemia due to dietary folate and vitamin B12 deficiency","volume":"2013","author":"Wollman","year":"1996","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s11899-012-0140-3","article-title":"Dysplasia has a differential diagnosis: distinguishing genuine myelodysplastic syndromes (MDS) from mimics, imitators, copycats and impostors","volume":"2013","author":"Steensma","year":"2012","journal-title":"Curr Hematol Malig Rep"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000322941","article-title":"Vitamin B 12 responsive pancytopenia mimicking myelodysplastic syndrome","volume":"2013","author":"Kim","year":"2011","journal-title":"Acta Haematol"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.6","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00277-012-1488-0","article-title":"Severe pernicious anemia with distinct cytogenetic and flow cytometric aberrations mimicking myelodysplastic syndrome","volume":"2013","author":"Parmentier","year":"2012","journal-title":"Ann Hematol"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00043426-199605000-00014","article-title":"Pancytopenia with chromosomal fragility: vitamin B12 deficiency","volume":"2013","author":"Chintagumpala","year":"1996","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025042708315969000_2013.jul08_1.bcr2013010200.8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"2013","author":"Vardiman","year":"2009","journal-title":"Blood"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:32:10Z","timestamp":1745767930000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,8]]},"references-count":8,"alternative-id":["10.1136\/bcr-2013-010200"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010200","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,7,8]]}}}