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Laboratory investigations revealed a normochromic normocytic anaemia, leucopenia and lymphopenia. Serum chemistries were normal. CT of the brain was normal. Lumbar puncture revealed an opening pressure of greater than 300\u2005mm\u2005H<jats:sub>2<\/jats:sub>O; cerebrospinal fluid (CSF) analysis was normal. HIV antibodies were non-reactive. Despite treatment with acetazolamide she developed somnolence. Hence MR venography was performed which showed no evidence of cerebral vein thrombosis. Further investigations revealed a positive direct coombs test, positive antinuclear antibodies (ANA) positive antidouble-stranded DNA (dsDNA) and false positive VDRL. Complement levels were reduced. Anti-Smith, anticardiolipin antibodies and lupus anticoagulant were negative.<\/jats:p>","DOI":"10.1136\/bcr-2013-010223","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T08:58:46Z","timestamp":1376384326000},"page":"bcr2013010223","source":"Crossref","is-referenced-by-count":11,"title":["Idiopathic intracranial hypertension as an initial presentation of systemic lupus erythematosus"],"prefix":"10.1136","volume":"2013","author":[{"given":"Keisha","family":"Maloney","sequence":"first","affiliation":[{"name":"University of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1053\/berh.2002.0259","article-title":"Epidemiology of systemic lupus erythematosus","volume":"2013","author":"Petri","year":"2002","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/art.22305","article-title":"Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study","volume":"2013","author":"Hanly","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.3","doi-asserted-by":"crossref","first-page":"835fa","DOI":"10.1177\/0961203306073133","article-title":"Mortality related to cerebrovascular disease in systemic lupus erythematosus","volume":"2013","author":"Bernatsky","year":"2006","journal-title":"Lupus"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.4","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"2013","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F","article-title":"The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes","volume":"2013","author":"ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature","year":"1999","journal-title":"Arthritis Rheum"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.6","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1212\/01.WNL.0000029570.69134.1B","article-title":"Diagnostic criteria for idiopathic intracranial hypertension","volume":"2013","author":"Friedman","year":"2002","journal-title":"Neurology"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/ard.54.3.159","article-title":"Controversies in lupus: nervous system involvement","volume":"2013","author":"Bruyn","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semarthrit.2010.08.001","article-title":"Neuropsychiatric syndromes in systemic lupus erythematosus: a metanalysis","volume":"2013","author":"Unterman","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11910-008-0015-0","article-title":"Idiopathic intracranial hypertension","volume":"2013","author":"Wall","year":"2008","journal-title":"Curr Neurol Neurosci"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11910-004-0024-6","article-title":"Pseudotumor cerebri","volume":"2013","author":"Brazis","year":"2004","journal-title":"Curr Neurol Neurosci"},{"key":"2025082704004612000_2013.aug13_1.bcr2013010223.11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archopht.1968.00980050191007","article-title":"Papilledema and asymptomatic intracranial hypertension in systemic lupus erythematosus. 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