{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:40:02Z","timestamp":1745772002303,"version":"3.40.4"},"reference-count":4,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 57-year-old Caucasian man with a history of Child\u2019s class A hepatitis C, cirrhosis and progressive multifocal hepatocellular carcinoma was treated with sorafenib but progressed after 7\u2005months of stable disease. At progression he was given salvage chemotherapy consisting of 5-fluorouracil and leucovorin and went into complete radiographic remission after 12 cycles of treatment. He did develop a portal vein thrombosis but nevertheless his hepatic lesions continued to resolve. Throughout his therapy \u03b1-fetoprotein (AFP) levels decreased only minimally. He did not seek retreatment after 14 cycles of chemotherapy and presented 3\u2005months later with relapsed disease on CT scans with markedly elevated AFP levels. He received one more chemotherapy cycle but was unable to tolerate further treatment, succumbing to his disease 3\u2005months thereafter, and a total of 29\u2005months after he was deemed a sorafenib failure.<\/jats:p>","DOI":"10.1136\/bcr-2013-010362","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T11:24:14Z","timestamp":1379330654000},"page":"bcr2013010362","source":"Crossref","is-referenced-by-count":2,"title":["Complete radiographic remission with 5-fluorouracil and leucovorin after sorafenib failure in hepatocellular carcinoma: Is there a role for chemotherapy after targeted agents?"],"prefix":"10.1136","volume":"2013","author":[{"given":"Jocelyn","family":"Tan-Shalaby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"2025042709175471000_2013.sep16_1.bcr2013010362.1","doi-asserted-by":"crossref","first-page":"11851","DOI":"10.1158\/0008-5472.CAN-06-1377","article-title":"Sorafenib blocks the RAF\/MEK\/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC\/PRF\/5","volume":"2013","author":"Liu","year":"2006","journal-title":"Cancer Res"},{"key":"2025042709175471000_2013.sep16_1.bcr2013010362.2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/COC.0b013e3181d31ed2","article-title":"Clinical outcomes of sorafenib treatment in patients with metastatic hepatocellular carcinoma who had been previously treated with fluoropyrimidine plus platinum-based chemotherapy","volume":"2013","author":"Kim","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"2025042709175471000_2013.sep16_1.bcr2013010362.3","first-page":"3927","article-title":"Hepatic intra-arterial cetuximab in combination with 5-fluorouracil and cisplatin as salvage treatment for sorafenib-refractory hepatocellular carcinoma","volume":"2013","author":"Poggi","year":"2011","journal-title":"Anticancer Res"},{"key":"2025042709175471000_2013.sep16_1.bcr2013010362.4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/MEG.0b013e328336565a","article-title":"Complete response of hepatocellular carcinoma with systemic combination chemotherapy: not to get out the chemotherapy?","volume":"2013","author":"Boschetti","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:18:05Z","timestamp":1745770685000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,16]]},"references-count":4,"alternative-id":["10.1136\/bcr-2013-010362"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010362","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,9,16]]}}}