{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:08:57Z","timestamp":1756462137775,"version":"3.40.4"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>This case is of a 39-year-old Filipino woman who within 2 months developed, Cushing's features she had no known comorbidities and no history of steroid intake. The patient also presented with hyperpigmentation of knuckles and toes, metabolic alkalosis and persistent hypokalaemia noted as proximal muscle weakness. The patient was referred to our institution for acutely worsening behavioural and psychiatric changes. Work-up for endogenous Cushing's syndrome revealed a significant adrenocorticotropic hormone production from an ectopic source. Further imaging was requested to locate the tumour, but the patient eventually succumbed to the drastic complications of hypercortisolism. On autopsy, the patient was found to have an ectopic well-differentiated neuroendocrine tumour located at the pancreatic head with metastasis to the right hepatic lobe.<\/jats:p>","DOI":"10.1136\/bcr-2013-010368","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T12:34:11Z","timestamp":1373978051000},"page":"bcr2013010368","source":"Crossref","is-referenced-by-count":3,"title":["Fountain of steroid from an ectopic ACTH-producing tumour"],"prefix":"10.1136","volume":"2013","author":[{"given":"Tom Edward Ngo","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Alegado","family":"Jimeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.1","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1200\/JCO.2005.04.4859","article-title":"Changing epidemiology of small-cell lung cancer in the United States over the last 30\u2005years: analysis of the surveillance, epidemiologic, and end results database","volume":"2013","author":"Govindan","year":"2006","journal-title":"J Clin Oncol"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.2","unstructured":"Adler GK . Cushing syndrome. Medscape Reference, (updated) 4 Mar 2013. http:\/\/emedicine.medscape.com\/article\/117365-overview"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.3","first-page":"1057","article-title":"The ectopic ACTH syndrome","volume":"2013","author":"Liddle","year":"1965","journal-title":"Cancer Res"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.4","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/1097-0142(197505)35:5<1430::AID-CNCR2820350529>3.0.CO;2-O","article-title":"Studies on ectopic ACTH-producing tumors. II. Clinical and biochemical features of 30 cases","volume":"2013","author":"Imura","year":"1975","journal-title":"Cancer"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.5","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1210\/jc.2004-2527","article-title":"Cushing's syndrome due to ectopic corticotropin secretion: twenty years\u2019 experience at the National Institutes of Health","volume":"2013","author":"Ilias","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.6","first-page":"3617","article-title":"11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome","volume":"2013","author":"Stewart","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2025042708373165000_2013.jul16_1.bcr2013010368.7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1148\/radiology.172.1.2544919","article-title":"Ectopic adrenocorticotropic hormone syndrome: localization studies in 28 patients","volume":"2013","author":"Doppman","year":"1989","journal-title":"Radiology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-010368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:37:38Z","timestamp":1745768258000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-010368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,16]]},"references-count":7,"alternative-id":["10.1136\/bcr-2013-010368"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-010368","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,7,16]]}}}