{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:16:05Z","timestamp":1756383365393,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>We report two probable cases of delayed presentation of ACE inhibitor (ACEi)-induced angio-oedema. The first patient was on ACEi for more than 10\u2005years while the second one was on it for 7\u2005years. Both the patients presented with initial unilateral swelling of the tongue which progressed further to involve the soft tissues of the oropharynx, head and neck leading to a compromised airway needing awake fibreoptic intubation and were managed successfully in the intensive care unit (ICU). C1 esterase inhibitor and mast cell tryptase level was normal for both patients. Both were treated with intravenous antihistamines and corticosteroids in the ICU. Both patients were successfully extubated within 72\u2005h and transferred to a medical ward. Age above 65\u2005years, atopy and non-steroidal anti-inflammatory drug use may have been the predisposing factors. Both patients made a full recovery with no complications and the ACEi was ceased.<\/jats:p>","DOI":"10.1136\/bcr-2013-010453","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T08:01:03Z","timestamp":1375084863000},"page":"bcr2013010453","source":"Crossref","is-referenced-by-count":7,"title":["Delayed presentation of ACE inhibitor-induced angio-oedema"],"prefix":"10.1136","volume":"2013","author":[{"given":"Guy","family":"Amey","sequence":"first","affiliation":[{"name":"Department of ICU, Robina Hospital, Gold Coast, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasan","family":"Waidyasekara","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanathan","family":"Kollengode","sequence":"additional","affiliation":[{"name":"Department of ICU, Robina Hospital, Gold Coast, Queensland, Australia"},{"name":"Department of ICU, Prince Charles Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"2025082801031702000_2013.jul29_1.bcr2013010453.1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/lary.22349","article-title":"Management of angiotensin-converting enzyme inhibitor-induced angioedema","volume":"2013","author":"Al-Khudari","year":"2011","journal-title":"Laryngoscope"},{"key":"2025082801031702000_2013.jul29_1.bcr2013010453.2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/bmj.304.6832.941","article-title":"Angio-oedema in relation to treatment with angiotensin converting enzyme inhibitors","volume":"2013","author":"Hedner","year":"1992","journal-title":"BMJ"},{"key":"2025082801031702000_2013.jul29_1.bcr2013010453.3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1253\/jcj.60.166","article-title":"A case report of angioedema during long-term (66\u2005months) angiotensin converting enzyme inhibition therapy with enalapril","volume":"2013","author":"Shionoiri","year":"1996","journal-title":"Jpn Circ J"},{"key":"2025082801031702000_2013.jul29_1.bcr2013010453.4","first-page":"33","article-title":"Delayed angiotensin-converting enzyme inhibitor-induced angioedema","volume":"2013","author":"Hameed","year":"2006","journal-title":"Hosp Physician"},{"key":"2025082801031702000_2013.jul29_1.bcr2013010453.5","doi-asserted-by":"crossref","unstructured":"Illing EJ Kelly S Hobson JC . 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