{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:26:17Z","timestamp":1759541177626,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 44-year-old woman presented with a large pelvic mass. Pathology revealed a granulosa cell tumour of the left ovary. The patient was followed after surgery with inhibin B levels and interval imaging. Six years later, she began to experience severe back pain. A vertebral biopsy was positive for metastatic granulosa cell tumour. She underwent radiation to the spine. Inhibin B levels began to rise and, several months later, a CT scan showed a large heterogeneous mass essentially replacing the left kidney. She underwent an open left radical nephrectomy. Pathology revealed a 12\u2005cm cystic nephroma with a 5\u2005cm nodule of metastatic granulosa cell tumour. Immunohistochemistry demonstrated that the mass was inhibin and oestrogen receptor positive. This is a novel presentation of these coexisting pathologies. This unique case sheds light on the possibility of induction of cystic nephroma by the altered hormonal environment created by a granulosa cell tumour metastasis.<\/jats:p>","DOI":"10.1136\/bcr-2013-200010","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T07:04:30Z","timestamp":1373439870000},"page":"bcr2013200010","source":"Crossref","is-referenced-by-count":4,"title":["Renal metastasis of an ovarian granulosa cell tumour inducing growth of a cystic nephroma"],"prefix":"10.1136","volume":"2013","author":[{"given":"Erin M","family":"Burns","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S","family":"Rosoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M","family":"Picard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Timothy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C","family":"Picard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.pap.0000201831.77472.d3","article-title":"Renal cystic diseases: a review","volume":"2013","author":"Bisceglia","year":"2006","journal-title":"Adv Anat Pathol"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/PAS.0b013e3181852105","article-title":"Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence","volume":"2013","author":"Zhou","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.3","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.urology.2007.11.106","article-title":"Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic and pathologic characteristics","volume":"2013","author":"Lane","year":"2008","journal-title":"Urology"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.4","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.5858\/2004-128-1404-CNAHAI","article-title":"Cystic nephroma: a histologic and immunohistochemical study of 10 cases","volume":"2013","author":"Mukhopadhyay","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/PAS.0b013e31802bdd56","article-title":"Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term","volume":"2013","author":"Turbiner","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5858\/2006-130-80-MEASTO","article-title":"Mixed epithelial and stromal tumor of the kidney and cystic nephroma share overlapping features: reappraisal of 15 lesions","volume":"2013","author":"Antic","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00261-007-9197-1","article-title":"Recurrent ovarian granulosa cell tumors: clinical and imaging features","volume":"2013","author":"Rha","year":"2008","journal-title":"Abdom imaging"},{"key":"2025042708323117000_2013.jul08_2.bcr2013200010.8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1200\/JCO.2003.10.019","article-title":"Granulosa cell tumor of the ovary","volume":"2013","author":"Schumer","year":"2003","journal-title":"J Clin Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-200010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:32:40Z","timestamp":1745767960000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-200010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":8,"alternative-id":["10.1136\/bcr-2013-200010"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-200010","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}