{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:10:01Z","timestamp":1745770201443,"version":"3.40.4"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Benign goitres have the potential to reach massive sizes if neglected, but most have a protracted course that may or may not present with compressive symptoms. We report the case of a 57-year-old man who presented with a rapidly enlarging nodular goitre resulting in acute respiratory failure. Endotracheal intubation and emergency total thyroidectomy were performed, revealing massive thyroid nodules with minimal intrathoracic extension and tracheal erosion. Despite a course and clinical findings suggestive of malignant disease, histopathology was consistent with a benign multinodular goitre. Several cases of benign goitres necessitating endotracheal intubation have been reported. Airway compromise was attributed to a significant intrathoracic component, or inciting events such as thyroid haemorrhage, pregnancy, radioiodine uptake or major surgery. Obstructive symptoms may not correlate well with objective measures of upper airway obstruction such as radiographs or flow volume loops.<\/jats:p>","DOI":"10.1136\/bcr-2013-200027","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T12:49:27Z","timestamp":1374497367000},"page":"bcr2013200027","source":"Crossref","is-referenced-by-count":2,"title":["Acute respiratory failure in a rapidly enlarging benign cervical goitre"],"prefix":"10.1136","volume":"2013","author":[{"given":"Carlo Jan","family":"Garingarao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecille","family":"A\u00f1onuevo-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Gasacao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.1","first-page":"1e14","article-title":"Goiter and other iodine deficiency disorders: a systematic review of epidemiological studies to deconstruct the complex web","volume":"2013","author":"Kotwal","year":"2007","journal-title":"Arch Med Res"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.15605\/jafes.027.01.04","article-title":"The Philippine Thyroid Diseases Study (PhilTiDeS 1): prevalence of thyroid disorders among adults in the Philippines","volume":"2013","author":"Carlos-Raboca","year":"2012","journal-title":"J ASEAN Federation Endocr Soc"},{"issue":"s1","key":"2025042708385674000_2013.jul22_1.bcr2013200027.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/10024.GL","article-title":"Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules","volume":"2013","author":"Gharib","year":"2010","journal-title":"Endocr Pract"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.4","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jcem.84.11.6115","article-title":"Immediate causes of death in thyroid carcinoma: clinicopathological analysis of 161 fatal cases","volume":"2013","author":"Kitamura","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.5","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/1097-0142(19881001)62:7<1381::AID-CNCR2820620724>3.0.CO;2-R","article-title":"Mortality from papillary thyroid carcinoma: a case-control study of 56 lethal cases","volume":"2013","author":"Smith","year":"1988","journal-title":"Cancer"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0030-6665(20)31264-0","article-title":"Surgery for benign thyroid disease causing tracheoesophageal compression","volume":"2013","author":"Shaha","year":"1990","journal-title":"Otolaryngol Clin North Am"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00268-012-1447-x","article-title":"Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from and endemic goiter region","volume":"2013","author":"Agarwal","year":"2012","journal-title":"World J Surg"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.8","first-page":"191","article-title":"Acute respiratory failure and tracheal obstruction in the elderly with benign goitres","volume":"2013","author":"Warren","year":"1979","journal-title":"CMA J"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.9","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/021849230601400514","article-title":"Multinodular Goiter compressing the trachea following open heart surgery","volume":"2013","author":"Sajja","year":"2006","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.10","first-page":"1","article-title":"Benign cervical multi-nodular goiter presenting with acute airway obstruction: a case report","volume":"2013","author":"Sharma","year":"2010","journal-title":"J Med Case Rep"},{"key":"2025042708385674000_2013.jul22_1.bcr2013200027.11","first-page":"1","article-title":"Emergency total thyroidectomy due to non-traumatic disease. 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