{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:45:45Z","timestamp":1758815145692,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>We present the case of a 60-year-old woman who developed peripheral T-cell lymphoma following successful treatment for high-grade B-cell non-Hodgkin's lymphoma. We consider the possible aetiology of this unusual occurrence. We hypothesise that this case represents one of the undiagnosed adult-onset immunodeficiency, in which the pathogenesis of the patient's T-cell lymphoma may have been in part iatrogenic, namely related to previous immunotherapy with rituximab. We feel this case highlights the importance of rebiopsy in patients with recurrent lymphadenopathy and a history of haematological malignancy and hence acts as an important aide memoir in the investigation of such cases.<\/jats:p>","DOI":"10.1136\/bcr-2013-200079","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T11:58:30Z","timestamp":1387195110000},"page":"bcr2013200079","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["The development of peripheral T-cell lymphoma after successful treatment for diffuse large B-cell lymphoma in a patient with suspected adult onset immunodeficiency: more questions than answers?"],"prefix":"10.1136","volume":"2013","author":[{"given":"Mari Frances","family":"Kilner","sequence":"first","affiliation":[{"name":"Department of Haematology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Merante","sequence":"additional","affiliation":[{"name":"Department of Haematology, James Cook University Hospital, Middlesbrough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandr","family":"Svec","sequence":"additional","affiliation":[{"name":"Department of Pathology, James Cook University Hospital, Middlesbrough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.1","doi-asserted-by":"publisher","DOI":"10.1309\/PH2BK79HAVTTPW13"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318181a826"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.3","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood.V93.7.2427","article-title":"Peripheral T-cell lymphoma following rituximab therapy for B-cell lymphoma","volume":"93","author":"Micallef","year":"1999","journal-title":"Blood"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.4","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1200\/JCO.1998.16.4.1635","article-title":"Peripheral T cell lymphoma after anti-CD20 antibody therapy","volume":"16","author":"Tetreault","year":"1998","journal-title":"J Clin Oncol"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-323238"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.6","unstructured":"Swerdlow SH Campo E Harris NL . WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edn. Lyon, France: IARC Press, 2008."},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124545"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.8","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4799"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.9","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2823"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.10","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0528-6"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07715.x"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.186"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.13","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200407000-00002"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.14","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1182\/blood.V87.9.3795.bloodjournal8793795","article-title":"Persistent clonal excess and skewed T-cell repertoire in T cells from patients with hairy cell leukemia","volume":"87","author":"Kluin-Nelemans","year":"1996","journal-title":"Blood"},{"key":"2025082805151104000_2013.dec16_1.bcr2013200079.15","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199212000-00004"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-200079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:15:21Z","timestamp":1756383321000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-200079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":15,"alternative-id":["10.1136\/bcr-2013-200079"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-200079","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}