{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:40:02Z","timestamp":1745772002890,"version":"3.40.4"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 61-year-old man with AIDS on chronic highly active antiretroviral treatment (HAART) presented with lethargy and jaundice and was found to have abnormal liver function tests (LFTs). Investigations including viral\/autoimmune markers and imaging were unrevealing, except for positive Epstein-Barr virus. HAART was held, however, transaminases and total bilirubin continued to rise. The liver biopsy revealed classical Hodgkin's lymphoma (HL). HL presenting only with liver findings without lymphadenopathy is rare. Extreme cases can lead to fulminant liver failure. The bone marrow biopsy and dramatic elevation in serum ferritin were consistent with haemophagocytic lymphohistiocytosis. Finding a chemotherapy regimen was challenging given abnormal LFTs and HAART interactions. Initial chemotherapy regimen has successfully decreased LFTs; however, it was limited by pancytopenia. The patient's regimen was changed, however second regimen was complicated by neuropathy. LFTs improved and the patient was able to receive the standard care chemotherapy for HL with significant clinical, laboratory and radiological improvement.<\/jats:p>","DOI":"10.1136\/bcr-2013-200113","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T14:19:12Z","timestamp":1377267552000},"page":"bcr2013200113","source":"Crossref","is-referenced-by-count":1,"title":["Unusual cause of cholestatic jaundice in a patient with AIDS"],"prefix":"10.1136","volume":"2013","author":[{"given":"Su Bin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makardhwaj Sarvadaman","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus M","family":"Anampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Strakhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"2025042709075265000_2013.aug23_1.bcr2013200113.1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s002770050186","article-title":"Hodgkin's disease presenting as a cholestatic febrile illness: incidence and main characteristic in a series of 421 patients","volume":"2013","author":"Cervantes","year":"1996","journal-title":"Ann Hematol"},{"key":"2025042709075265000_2013.aug23_1.bcr2013200113.2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1080\/02841860701644078","article-title":"Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: statistical analysis of all published cases and literature review","volume":"2013","author":"Ballonoff","year":"2008","journal-title":"Acta Oncol"},{"key":"2025042709075265000_2013.aug23_1.bcr2013200113.3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009","volume":"2013","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"2025042709075265000_2013.aug23_1.bcr2013200113.4","doi-asserted-by":"crossref","unstructured":"Jacobson CA Abramson JS . HIV-associated Hodgkin's lymphoma: prognosis and therapy in the era of cART. 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