{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:10:02Z","timestamp":1745770202081,"version":"3.40.4"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Fibrous dysplasia (FD) is a benign bone disorder presenting with a variety of clinical manifestations. This is the first reported case of anosmia as presenting symptom of FD. We present the case of a 72-year-old female patient with a progressive olfactory dysfunction. Clinical examination revealed evidence of chronic rhinosinusitis; therefore the patient was treated with a course of oral corticosteroids. The patient had no improvement in her olfactory ability and imaging studies were ordered. Bony lesions characteristic of craniofacial FD were found, causing obstruction of the central olfactory pathway. This case emphasises the need to conduct further investigations in patients with rhinosinusitis and olfactory dysfunction especially when they present no response to oral steroid treatment.<\/jats:p>","DOI":"10.1136\/bcr-2013-200432","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T16:30:33Z","timestamp":1374856233000},"page":"bcr2013200432","source":"Crossref","is-referenced-by-count":0,"title":["Olfactory dysfunction as first presenting symptom of cranial fibrous dysplasia"],"prefix":"10.1136","volume":"2013","author":[{"given":"Evangelia","family":"Tsakiropoulou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iordanis","family":"Konstantinidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Chatziavramidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannis","family":"Constantinidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1746-160X-5-22","article-title":"The nature of fibrous dysplasia","volume":"2013","author":"Feller","year":"2009","journal-title":"Head Face Med"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/014556130408300107","article-title":"Fibrous dysplasia of the frontal sinus","volume":"2013","author":"Rojas","year":"2004","journal-title":"Ear Nose Throat J"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.3","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/eye.2009.6","article-title":"Craniofacial fibrous dysplasia: clinical characteristics and long-term outcomes","volume":"2013","author":"Rahman","year":"2009","journal-title":"Eye"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s004050050223","article-title":"Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination and olfactory thresholds","volume":"2013","author":"Kobal","year":"2000","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/archotol.127.10.1239","article-title":"Fibrous dysplasia involving the skull base and temporal bone","volume":"2013","author":"Lustig","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"unstructured":"Van Tilburg W . Fibrous dysplasia. In: Vinken PJ Bruyn GW . eds. Handbook of clinical neurology. Amsterdam: North Holland Publishing, 1972:163\u2013212.","key":"2025042708534262000_2013.jul26_1.bcr2013200432.6"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1054\/jocn.2002.1056","article-title":"Symptomatic cranial fibrous dysplasias: clinico-radiological analysis in a series of eight operative cases with follow-up results","volume":"2013","author":"Sharma","year":"2002","journal-title":"J Clin Neurosci"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1017\/S0022215100116974","article-title":"Craniofacial fibrous dysplasia","volume":"2013","author":"Camilleri","year":"1991","journal-title":"J Laryngol Otol"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.9","first-page":"342","article-title":"Craniofacial fibrous dysplasia presenting with visual impairment","volume":"2013","author":"Alam","year":"2003","journal-title":"MJAFI"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.10","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00005537-199710000-00008","article-title":"Fibrous dysplasia of the temporal bone: reversal of sensorineural hearing loss after decompression of the internal auditory canal","volume":"2013","author":"Morrissey","year":"1997","journal-title":"Laryngoscope"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pedex.2006.03.003","article-title":"Dizziness as presenting symptom of monostotic fibrous dysplasia","volume":"2013","author":"Grasso","year":"2006","journal-title":"Int J Pediatr Otorhinolaryngol Extra"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.12","first-page":"47","article-title":"Olfactory mucosa in nasal polyposis: implications for FESS outcome","volume":"2013","author":"Konstantinidis","year":"2010","journal-title":"Rhinology"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/194589240602000120","article-title":"Computed tomography scans in the evaluation of patients with olfactory dysfunction","volume":"2013","author":"Mueller","year":"2006","journal-title":"Am J Rhinol"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/jnnp.70.2.218","article-title":"Olfactory function in patients with olfactory groove meningioma","volume":"2013","author":"Welge-Luessen","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1440-1673.2008.01963.x","article-title":"Imaging of craniofacial fibrous dysplasia","volume":"2013","author":"Lisle","year":"2008","journal-title":"J Med Imaging Radiat Oncol"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.16","first-page":"543","article-title":"Craniofacial fibrous dysplasia: an update","volume":"2013","author":"Chen","year":"2006","journal-title":"Chang Gung Med J"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.17","first-page":"49","article-title":"Radiological difficulties in the diagnosis of fibrous dysplasia of the sphenoid sinus and the cranial base","volume":"2013","author":"Khalil","year":"2001","journal-title":"Rhinology"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.18","doi-asserted-by":"crossref","first-page":"e25179","DOI":"10.1371\/journal.pone.0025179","article-title":"Surgery versus watchful waiting in patients with craniofacial fibrous dysplasia\u2014a meta-analysis","volume":"2013","author":"Amit","year":"2011","journal-title":"PLoSOne"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/MOO.0b013e32834e901c","article-title":"Fibrous dysplasia of the sinonasal tract and adjacent skull base","volume":"2013","author":"Schreiber","year":"2012","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2025042708534262000_2013.jul26_1.bcr2013200432.20","first-page":"114","article-title":"Medical therapy in adults with fibrous dysplasia of bone","volume":"2013","author":"Chapurlat","year":"2007","journal-title":"J Bone Miner Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-200432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:53:50Z","timestamp":1745769230000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-200432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":20,"alternative-id":["10.1136\/bcr-2013-200432"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-200432","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}