{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:53:56Z","timestamp":1782604436092,"version":"3.54.5"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Primary small cell carcinoma of the oesophagus is a rare, highly aggressive malignancy with diagnosis usually occurring at the most advanced stages. We report a case of small cell carcinoma of the oesophagus presenting with dysphagia and melena. A 79-year-old Caucasian man presented to an outside hospital with dizziness, light-headedness, chest pain and melena for 3\u2005days. He had a history of intermittent dysphagia for solids and a 25-pound weight loss in the past 2\u2005months. He underwent an esophagogastroduodenoscopy that revealed a large polypoid, well-circumscribed friable oesophageal mass causing near complete obstruction of the lumen. This mass extended into the gastric cardia. Oesophageal biopsies were consistent with small cell neuroendocrine carcinoma. He underwent chemotherapy with subsequent remission and developed recurrence of disease in the oesophagus 2\u2005years later. Overall, the patient has had two recurrences of his disease but has survived for more than 2\u2005years with chemotherapy alone.<\/jats:p>","DOI":"10.1136\/bcr-2013-200468","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T06:38:26Z","timestamp":1378190306000},"page":"bcr2013200468","source":"Crossref","is-referenced-by-count":5,"title":["Small cell carcinoma of the oesophagus: a rare cause of dysphagia"],"prefix":"10.1136","volume":"2013","author":[{"given":"Theresa","family":"Schuerle","sequence":"first","affiliation":[{"name":"West Penn Allegheny Health System, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Aoun","sequence":"additional","affiliation":[{"name":"West Penn Allegheny Health System, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Farah","sequence":"additional","affiliation":[{"name":"West Penn Allegheny Health System, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.1","first-page":"1334","article-title":"A case of primary small cell carcinoma of the esophagus responding remarkably to carboplatin (CBDCA)+etoposide (VP-16) combination therapy and radiation therapy","volume":"2013","author":"Aizawa","year":"2009","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1442-2050.2002.00244.x","article-title":"Effectiveness of preoperative chemotherapy using carboplatin (CBDCA) and surgery against an esophageal small cell carcinoma","volume":"2013","author":"Makino","year":"2002","journal-title":"Dis Esophagus"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/030089161009600524","article-title":"Small cell\/neuroendocrine tumors of the esophagus: presentation of two cases and review of the literature","volume":"2013","author":"Gollard","year":"2010","journal-title":"Tumori"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/annonc\/mdm476","article-title":"Small-cell carcinoma of the esophagus and gastroesophageal junction: review of the Memorial Sloan-Kettering experience","volume":"2013","author":"Ku","year":"2008","journal-title":"Ann Oncol"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/path.1700640420","article-title":"Oat-cell carcinoma of the oesophagus","volume":"2013","author":"Mckeown","year":"1952","journal-title":"J Path Bacteriol"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2407-7-38","article-title":"Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases","volume":"2013","author":"Yun","year":"2007","journal-title":"BMC Cancer"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.7","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.3748\/wjg.v10.i24.3680","article-title":"Primary small cell carcinoma of esophagus: report of 9 cases and review of literature","volume":"2013","author":"Wu","year":"2004","journal-title":"World J Gastroenterol"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000421-200010000-00005","article-title":"Small cell carcinoma of the esophagus","volume":"2013","author":"Bennouna","year":"2000","journal-title":"Am J Clin Oncol"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.9","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s11605-013-2204-7","article-title":"Management of small cell carcinoma of esophagus in China","volume":"2013","author":"Lu","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"2025082803335918000_2013.sep03_1.bcr2013200468.10","unstructured":"Zhu Y Qui B Liu H . Primary small cell carcinoma of the esophagus: review of 64 cases from a single institution. Dis Esophagus. 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Cancer management: a multidisciplinary approach: medical, surgical and radiation oncology. 7th edn. October 2003."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-200468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:34:09Z","timestamp":1756377249000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-200468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,3]]},"references-count":14,"alternative-id":["10.1136\/bcr-2013-200468"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-200468","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,3]]}}}