{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:00:28Z","timestamp":1758862828658,"version":"3.40.4"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Guillain-Barr\u00e9 syndrome (GBS) constitutes a heterogeneous group of immune-mediated peripheral neuropathic disorders that can be triggered by a variety of antecedent events. Clinical symptoms are thought to result from streptokinase antibody-mediated damage to the local blood\u2013nerve barrier. We report the case of a 50-year-old man with acute anterior wall myocardial infarction who developed GBS as a manifestation of autoimmune hypersensitivity reaction to the drug 17\u2005days after thrombolytic therapy with streptokinase. The patient was treated with a 5-day course of intravenous \u03b3 globulin and his symptoms improved and there was no residual deficit. The case forms a reminder of the autoimmune complications of non-fibrin specific agents that can sometimes be catastrophic and require persistent and vigilant in-hospital and immediate postdischarge follow-up and immediate management.<\/jats:p>","DOI":"10.1136\/bcr-2013-200602","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T11:32:53Z","timestamp":1381145573000},"page":"bcr2013200602","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Occurrence of Guillain-Barr\u00e9 syndrome as an immune mediated complication after thrombolysis with streptokinase for acute anterior wall myocardial infarction: a caution to be vigilant"],"prefix":"10.1136","volume":"2013","author":[{"given":"Basant","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Patra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C N","family":"Manjunath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,10,7]]},"reference":[{"key":"2025042709255634000_2013.oct07_1.bcr2013200602.1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0733-8619(05)70012-8","article-title":"Treatment approaches for GBS and chronic inflammatory demyelinating polyradiculoneuropathy","volume":"2013","author":"Lindenbaum","year":"2001","journal-title":"Neurol 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