{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:24:08Z","timestamp":1791217448500,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>ACE-inhibitor is an antihypertensive drug which is increasingly used to treat a wide range of medical conditions. A known adverse reaction is angio-oedema of the head and neck, which can become fatal when the upper airway is involved, causing asphyxia. We present a Caucasian man, who developed severe angio-oedema of the tongue and floor of the mouth. He was successfully treated with complement C1-concentrate causing the swelling to regress within 20\u2005min. This treatment option can be an effective alternative to bradykinin antagonists, which might not be available in the emergency room, or more invasive measures like intubation or emergency airway puncture.<\/jats:p>","DOI":"10.1136\/bcr-2013-200652","type":"journal-article","created":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T08:13:36Z","timestamp":1380874416000},"page":"bcr2013200652","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate"],"prefix":"10.1136","volume":"2013","author":[{"given":"Eva Rye","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Koege Hospital, Koege, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,10,4]]},"reference":[{"key":"2025082707484712000_2013.oct04_1.bcr2013200652.1","first-page":"A4449","article-title":"Increasing rate of angiotensin-converting enzyme inhibitor-related upper airway angio-oedema","volume":"2013","author":"Holm","year":"2012","journal-title":"Dan Med J"},{"key":"2025082707484712000_2013.oct04_1.bcr2013200652.2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jaci.2007.07.040","article-title":"Trends in hospitalizations for anaphylaxis, angio-oedema, and urticaria in Australia, 1993\u20131994 to 2004-2005","volume":"2013","author":"Poulos","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2025082707484712000_2013.oct04_1.bcr2013200652.3","doi-asserted-by":"crossref","unstructured":"Wright J Musini V . 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