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The necrotic tissue was resected and a skin graft was harvested from the thigh. She was offered DIEP-flap reconstruction 8\u2005months later. There were no complications, except for marginal necrosis of the flap. Necrosectomy was performed and resolved through an advancement flap.<\/jats:p>","DOI":"10.1136\/bcr-2013-201179","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T14:32:53Z","timestamp":1382106773000},"page":"bcr2013201179","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Massive breast necrosis after extravasation of a full anthracycline cycle"],"prefix":"10.1136","volume":"2013","author":[{"given":"Ines","family":"Vasconcelos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Schoenegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"issue":"(Suppl 3)","key":"2025042709305369000_2013.oct18_1.bcr2013201179.1","doi-asserted-by":"crossref","first-page":"iii26","DOI":"10.1093\/annonc\/mdg744","article-title":"Extravasation: a dreaded complication of chemotherapy","volume":"2013","author":"Schrijvers","year":"2003","journal-title":"Ann Oncol"},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.2","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1200\/JCO.1995.13.11.2851","article-title":"Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study","volume":"2013","author":"Bertelli","year":"1995","journal-title":"J Clin Oncol"},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.3","first-page":"499","article-title":"Failure of DMSO and vitamin E to prevent doxorubicin skin ulceration in the mouse","volume":"2013","author":"Dorr","year":"1983","journal-title":"Cancer Treat Rep"},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00578557","article-title":"The limited role of corticosteroids in ameliorating experimental doxorubicin skin toxicity in the mouse","volume":"2013","author":"Dorr","year":"1980","journal-title":"Cancer Chemother Pharmacol"},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.5","first-page":"3680","article-title":"Treatment of anthracycline extravasation with dexrazoxane","volume":"2013","author":"Langer","year":"2000","journal-title":"Clin Cancer Res."},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/annonc\/mdl413","article-title":"Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies","volume":"2013","author":"Mouridsen","year":"2007","journal-title":"Ann Oncol"},{"key":"2025042709305369000_2013.oct18_1.bcr2013201179.7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1470-2045(04)01470-6","article-title":"Dexrazoxane for anthracycline extravasation and GM-CSF for skin ulceration and wound healing","volume":"2013","author":"El-Saghir","year":"2004","journal-title":"Lancet Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-201179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:30:58Z","timestamp":1745771458000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-201179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":7,"alternative-id":["10.1136\/bcr-2013-201179"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-201179","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}