{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:42:28Z","timestamp":1768002148827,"version":"3.49.0"},"reference-count":22,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous group of conditions characterised by autonomic dysfunction and an exaggerated sympathetic response to assuming an upright position. Up till recently, it was largely under-recognised as a clinical entity. There is now consensus about the definition of POTS as a greater than 30\/min heart rate increase on standing from a supine position (greater than 40\/min increase in 12\u201319-year-old patients) or an absolute heart rate of greater than 120\/min within 10\u2005min of standing from a supine position and in the absence of hypotension, arrhythmias, sympathomimetic drugs or other conditions that cause tachycardia. We present two cases of POTS, followed by a discussion of its pathogenesis, pathophysiology, epidemiology and management.<\/jats:p>","DOI":"10.1136\/bcr-2013-201244","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T11:24:14Z","timestamp":1379330654000},"page":"bcr2013201244","source":"Crossref","is-referenced-by-count":9,"title":["Postural orthostatic tachycardia syndrome (POTS)"],"prefix":"10.1136","volume":"2013","author":[{"given":"Bharat","family":"Sidhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nonyelum","family":"Obiechina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noman","family":"Rattu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanta","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"2025042709174127000_2013.sep16_1.bcr2013201244.1","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1161\/CIRCULATIONAHA.107.761643","article-title":"Postural tachycardia syndrome","volume":"2013","author":"Grubb","year":"2008","journal-title":"Circulation"},{"key":"2025042709174127000_2013.sep16_1.bcr2013201244.2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autneu.2011.02.004","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"2013","author":"Freeman","year":"2011","journal-title":"Auton Neurosci"},{"key":"2025042709174127000_2013.sep16_1.bcr2013201244.3","unstructured":"National Institute Of Neurological Disorders and Stroke (NINDS). 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