{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:21:41Z","timestamp":1771654901792,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,8,18]]},"abstract":"<jats:p>Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL) whereby individual lymphoma cells infiltrate the cerebral white matter without causing a mass effect. The disease characteristically presents as a rapidly progressive dementia, which opens an ample differential diagnosis of toxic, metabolic, neurodegenerative and infective causes. Other presentations also include changes in personality, myoclonus and psychotic symptoms. Here we report a patient who presented with a rapidly progressive dementia with a unique surgical history of a dural mater graft in the 1970s. The diagnosis of iatrogenic Creutzfeldt-Jakob disease (iCJD) was initially considered. However, the patient\u2019s clinical status deteriorated rapidly with no response to symptomatic treatment and she died 2\u2005months after symptom onset. A diagnosis of T-type LC was reached at autopsy.<\/jats:p>","DOI":"10.1136\/bcr-2013-201246","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T12:17:21Z","timestamp":1410178641000},"page":"bcr2013201246","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Lymphomatosis cerebri mimicking iatrogenic Creutzfeldt-Jakob disease"],"prefix":"10.1136","volume":"2014","author":[{"given":"Elena","family":"Rivero Sanz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Torralba Cabeza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Sanju\u00e1n","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Garc\u00eda-Bragado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/NRL.0b013e31820ba5e3","article-title":"The evaluation of rapidly progressive dementia","volume":"17","author":"Rosenbloom","year":"2001","journal-title":"Neurologist"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21430"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.3","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.514903"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.4","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006833"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61346-9"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-011-0064-y"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0721-y"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.8","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-559"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01023.x"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.10","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.120116"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161274798"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.12","doi-asserted-by":"publisher","DOI":"10.1586\/era.12.36"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.13","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.120"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.05.003"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.15","doi-asserted-by":"crossref","unstructured":"Bergner N Monsef I Illerhaus G . Role of chemotherapy additional to high dose methotrexate for primary central nervous system lymphoma (PCNSL) (Review). Cochrane Database Syst Rev 2012;(11):1\u201329.","DOI":"10.1002\/14651858.CD009355.pub2"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-009-0433-z"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.33588\/rn.3602.2002258","article-title":"T-type primary lymphoma of the central nervous system in immunocompetent patients","volume":"36","author":"Barrena-Carballo","year":"2003","journal-title":"Rev Neurol"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.18","first-page":"394","article-title":"Primary brain T-cell lymphoma during pregnancy","volume":"62","author":"Ilker","year":"2012","journal-title":"J Pak Med Assoc"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.10.024"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.20","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12005"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.21","first-page":"667","article-title":"Lymphomatosiscerebri as the cause of leukoencephalopathy","volume":"46","author":"deToledo","year":"2008","journal-title":"Rev Neurol"},{"key":"2025042706272414000_2014.sep08_1.bcr2013201246.22","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0931-3"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-201246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:27:36Z","timestamp":1745760456000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-201246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,8]]},"references-count":22,"alternative-id":["10.1136\/bcr-2013-201246"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-201246","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,8]]}}}