{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:23:23Z","timestamp":1769153003583,"version":"3.49.0"},"reference-count":68,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,2,3]]},"abstract":"<jats:p>A 50-year-old man presented with dyspnoea while sitting, standing and walking but resolved completely in supine position. On cardiorespiratory examinations, fine crackles were noted over bibasal area. Chest X-ray showed bilateral reticulonodular shadows, restrictive pattern on spirometry, elevated alveolar arterial O<jats:sub>2<\/jats:sub> gradient on arterial blood gas. High-resolution CT of the thorax revealed pattern as \u2018confident\u2019 or \u2018certain\u2019 radiographic diagnosis of idiopathic pulmonary fibrosis (IPF). Bubble-contrast echocardiography in recumbent, sitting and upright positions revealed no intracardiac (right to left shunt) or intrapulmonary shunts. This case highlights the necessity of awareness of this syndrome in cases of interstitial lung diseases (ILDs) also. Although 188 cases have been described thus far of platypnoea-orthodeoxia syndrome (P-OS) of various aetiologies, to the best of our knowledge, it is the first ever case of P-OS in ILD\/IPF. Both lung bases were predominantly affected in this patient, platypnoea and orthodeoxia were attributed to areas of low\/zero ventilation\/perfusion (V\/Q) ratio (zone 1 phenomena) as no other obvious explanation was found.<\/jats:p>","DOI":"10.1136\/bcr-2013-201284","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T16:09:24Z","timestamp":1434643764000},"page":"bcr2013201284","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Platypnoea-orthodeoxia syndrome: novel cause for a known condition"],"prefix":"10.1136","volume":"2014","author":[{"given":"Rajendra","family":"Takhar","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Peoples College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, 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