{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:10Z","timestamp":1756285810103,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Invasive pulmonary aspergillosis is a rare and fatal complication in patients with cystic fibrosis (CF) who lack concomitant risk factors. The few documented cases in children have all resulted in deaths during hospitalisation. We present the case of a 12-year-old boy with CF who was admitted for an exacerbation which was unresponsive to antibiotic therapy. The findings on imaging raised concerns about a possible fungal infection. As a result, voriconazole therapy was started prior to his respiratory deterioration. He was later found to be \u03b2-D glucan and <jats:italic>Aspergillus<\/jats:italic> Ag galactomannan positive confirming the suspicion for invasive pulmonary aspergillosis. Three months after diagnosis, he was discharged home under stable condition. Voriconazole was continued beyond discharge and resulted in improvement of respiratory symptoms. This underscores the importance of early treatment of pulmonary aspergillosis in patients with CF. Unfortunately, the patient died 6\u2005months after diagnosis from a CF exacerbation.<\/jats:p>","DOI":"10.1136\/bcr-2013-201360","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T08:54:35Z","timestamp":1384764875000},"page":"bcr2013201360","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Early diagnosis and treatment of invasive pulmonary aspergillosis in a patient with cystic fibrosis"],"prefix":"10.1136","volume":"2013","author":[{"given":"Ricardo Alberto","family":"Mosquera","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lila","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roya Mohebpour","family":"Clements","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy K","family":"Jon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, The University of Texas Health Science Center at Houston, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.00055-08","article-title":"Pathogenesis of Aspergillus fumigatus in invasive aspergillosis","volume":"2013","author":"Dagenais","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"(Suppl 3)","key":"2025082701331089000_2013.nov18_1.bcr2013201360.2","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1086\/376525","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis-state of the art: Cystic Fibrosis Foundation Consensus Conference","volume":"2013","author":"Stevens","year":"2003","journal-title":"Clin Infect Dis"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.3","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3109\/13693786.2012.676739","article-title":"Serum galactomannan in cystic fibrosis patients colonized with Aspergillus species","volume":"2013","author":"Warren","year":"2012","journal-title":"Med Mycol"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ccm.2012.02.003","article-title":"Allergic bronchopulmonary aspergillosis","volume":"2013","author":"Bains","year":"2012","journal-title":"Clin Chest Med"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.5","first-page":"843763","article-title":"Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis","volume":"2013","author":"Knutsen","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1099-0496(199902)27:2<130::AID-PPUL10>3.0.CO;2-1","article-title":"Fatal invasive aspergillosis in an adolescent with cystic fibrosis","volume":"2013","author":"Brown","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1164\/rccm.201106-1027OC","article-title":"Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation","volume":"2013","author":"Chadhary","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/INF.0b013e3181f63c90","article-title":"Invasive aspergillosis in cystic fibrosis: a fatal case in an adolescent and review of the literature","volume":"2013","author":"Massam","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00000441-198205000-00007","article-title":"Fatal disseminated aspergillosis in a previously well young adult with cystic fibrosis","volume":"2013","author":"Guidotti","year":"1982","journal-title":"Am J Med Sci"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ppul.1950170210","article-title":"Disseminated aspergillosis in a patient with cystic fibrosis and allergic bronchopulmonary aspergillosis","volume":"2013","author":"Chung","year":"1994","journal-title":"Pediatr Pulmonol"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12281-012-0127-5","article-title":"The role of biomarkers for diagnosis of and therapeutic decisions related to invasive aspergillosis in children","volume":"2013","author":"Fisher","year":"2013","journal-title":"Curr Fungal Infect Rep"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jpids\/pis044","article-title":"Galactomannan antigen testing for diagnosis of invasive aspergillosis in pediatric hematology patients","volume":"2013","author":"Fisher","year":"2012","journal-title":"J Pediatr Infect Dis Soc"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1086\/525258","article-title":"Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America","volume":"2013","author":"Walsh","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.14","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1128\/AAC.02226-12","article-title":"Pharmacodynamics and dose-response relationships of liposomal amphotericin B against different azole-resistant Aspergillus fumigatus isolates in a murine model of disseminated aspergillosis","volume":"2013","author":"Seyedmousavi","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jcf.2013.02.003","article-title":"What is the clinical significance of filamentous fungi positive sputum cultures in patients with cystic fibrosis?","volume":"2013","author":"Liu","year":"2013","journal-title":"J Cyst Fibros"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.16","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1086\/343743","article-title":"An unusual case of pulmonary invasive aspergillosis and aspergilloma cured with voriconazole in a patient with cystic fibrosis","volume":"2013","author":"Chow","year":"2002","journal-title":"Clin Infect Dis"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.17","first-page":"173","article-title":"Epidemiology, diagnosis and treatment of fungal respiratory infections in the critically ill patient","volume":"2013","author":"Garnacho-Montero","year":"2013","journal-title":"Rev Esp Quimioter"},{"key":"2025082701331089000_2013.nov18_1.bcr2013201360.18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ppul.21240","article-title":"Risk factors for Aspergillus colonization and allergic bronchopulmonary aspergillosis in children with cystic fibrosis","volume":"2013","author":"Jubin","year":"2010","journal-title":"Pediatr Pulmonol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-201360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:33:21Z","timestamp":1756283601000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-201360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":18,"alternative-id":["10.1136\/bcr-2013-201360"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-201360","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,11,18]]}}}