{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:06:17Z","timestamp":1775192777222,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 53-year-old man presented with sudden painless diminution of vision in his right eye for 3\u2005days. His fundus examination showed diffuse whitening of the retina with a cherry red spot at the fovea with cilioretinal artery sparing. On fluorescein angiography delayed arteriovenous transit was observed. Three-dimensional spectral domain optical coherence tomography was used to assess retinal nerve fibre layer thickness and average macular central subfield thickness on days 3, 7, 30 and 90. Marked retinal oedema due to ischaemia was observed on day 3 of occurrence of central retinal artery occlusion. On day 7, significant decrease in retinal nerve fibre thickness and macular thickness was noted suggestive of acute reperfusion injury. Retinal nerve fibre layer thickness and macular thickness returned to near normal on day 30 due to restoration of blood supply with wash out of stress mediators. Retinal atrophy was observed on day 90.<\/jats:p>","DOI":"10.1136\/bcr-2013-201415","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T10:07:44Z","timestamp":1382350064000},"page":"bcr2013201415","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Ischaemia-reperfusion injury in central retinal artery occlusion"],"prefix":"10.1136","volume":"2013","author":[{"given":"Sandeep","family":"Saxena","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nibha","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten H","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pallas Klinik, Olten, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Akduman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye institute, St Louis University, St Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,10,21]]},"reference":[{"key":"2025082804325476000_2013.oct21_1.bcr2013201415.1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0014-4835(03)00214-8","article-title":"Central retinal artery occlusion. 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