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A stereotactic brain biopsy revealed CD20 diffuse large B-cell lymphoma. The patient was started on high-dose intravenous methotrexate. She has received 11 cycles and has regained near normal function of the right arm. The patient's most recent brain MRI showed near complete resolution of all previously seen abnormal foci of enhancement.<\/jats:p>","DOI":"10.1136\/bcr-2013-201442","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T12:32:23Z","timestamp":1399293143000},"page":"bcr2013201442","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Isolated secondary CNS relapse in a case of stage I diffuse large B-cell lymphoma"],"prefix":"10.1136","volume":"2014","author":[{"given":"Yana G","family":"Najjar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriti","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeen N","family":"Faza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Dushkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Peereboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"2025042703334194000_2014.may05_1.bcr2013201442.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04749.x"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-101402"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1182\/asheducation-2002.1.283","article-title":"Central nervous system lymphoma","volume":"1","author":"Lister","year":"2002","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V47.1.3.3","article-title":"Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited","volume":"47","author":"Bunn","year":"1976","journal-title":"Blood"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861534"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-038257"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr440"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.9","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06091"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.10","first-page":"Doc11","article-title":"et al. 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Isolated central nervous system relapse in aggressive non-Hodgkin's lymphoma: the Bologna experience","volume":"32","author":"Zinzani","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"2025042703334194000_2014.may05_1.bcr2013201442.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.3441"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-201442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:33:47Z","timestamp":1745750027000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-201442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":13,"alternative-id":["10.1136\/bcr-2013-201442"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-201442","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,5,5]]}}}