{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T17:10:06Z","timestamp":1745773806173,"version":"3.40.4"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 43-year-old woman presented with a few weeks\u2019 history of discomfort and swelling in her left breast. She had undergone bilateral breast augmentation 8\u2005years previously. There were no risk factors for breast cancer. Clinical examination, mammography and breast ultrasound revealed a large left breast mass adjacent to the breast implant with enlarged axillary lymph nodes. Owing to diagnostic uncertainty, core biopsies were sent to a specialist unit which confirmed breast implant-associated anaplastic large cell lymphoma with involved lymph nodes. Staging investigations confirmed no distant disease. The lymphoma multidisciplinary team recommended cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy, followed by implant removal and local radiotherapy. However, the patient's disease progressed on first-line, and then second-line chemotherapy. She therefore had a mastectomy and axillary node clearance followed by radiotherapy, with a planned delayed left breast reconstruction and removal of the right breast implant.<\/jats:p>","DOI":"10.1136\/bcr-2013-201950","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T11:58:46Z","timestamp":1385553526000},"page":"bcr2013201950","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Chemotherapy-resistant breast implant-associated anaplastic large cell lymphoma"],"prefix":"10.1136","volume":"2013","author":[{"given":"Muralidharan","family":"Parthasarathy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Orrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Mortimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liz","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/1097-0142(197206)29:6<1705::AID-CNCR2820290640>3.0.CO;2-I","article-title":"Primary lymphoma of the breast","volume":"2013","author":"Wiseman","year":"1972","journal-title":"Cancer"},{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.2","unstructured":"Center for Devices and Radiological Health, US Food and Drug Administration. Anaplastic large cell lymphoma (ALCL) in women with breast implants: preliminary FDA findings and analyses. FDA\/CDRH; 2011. http:\/\/www.fda.gov\/downloads\/MedicalDevices\/ProductsandMedicalProcedures\/ImplantsandProsthetics\/BreastImplants\/UCM240003.pdf (accessed 4 Sep 2013)."},{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11899-013-0164-3","article-title":"Breast implant-associated anaplastic large cell lymphoma: a systematic review of the literature and mini-meta analysis","volume":"2013","author":"Thompson","year":"2013","journal-title":"Curr Hematol Malig Rep"},{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.4","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1158\/1078-0432.CCR-12-0101","article-title":"Survival signals and targets for therapy in breast implant-associated ALK-anaplastic large cell lymphoma","volume":"2013","author":"Lechner","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.5","first-page":"206","article-title":"Anaplastic large cell lymphoma, ALK negative","volume":"2013","author":"Ferreri","year":"2012","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025042709422022000_2013.nov27_1.bcr2013201950.6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/CEJ.0b013e328350b0ae","article-title":"Risk of lymphoma in women with breast implants: analysis of clinical studies","volume":"2013","author":"Largent","year":"2012","journal-title":"Eur J Cancer Prev"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-201950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:42:31Z","timestamp":1745772151000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-201950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":6,"alternative-id":["10.1136\/bcr-2013-201950"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-201950","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}