{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:10:06Z","timestamp":1745748606345,"version":"3.40.4"},"reference-count":3,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,2,6]]},"abstract":"<jats:p>A 46-year-old man had a smoke inhalation injury. Within 1\u2005month, he developed neuropsychiatric problems including toxic encephalopathy, cognitive disorder, depression symptoms and personality change. From 3 to 14\u2005years after the toxic inhalation injury, the patient received treatment with sertraline and methylphenidate. The<jats:sup>18<\/jats:sup>F-fluorodeoxyglucose positron emission tomography scan at 3\u2005years after injury showed deterioration of glucose metabolism in the hippocampus and orbital frontal region; at 14\u2005years after injury, the hippocampus had no significant change but the orbital frontal region had deterioration of glucose metabolism. It was hypothesised that sertraline may have provided selective hippocampal neuroprotection. Further study is justified to evaluate sertraline as a possible neuroprotective agent after smoke inhalation injury.<\/jats:p>","DOI":"10.1136\/bcr-2013-202157","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T11:45:52Z","timestamp":1393501552000},"page":"bcr2013202157","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Limiting progressive hippocampal metabolic abnormalities after smoke inhalation injury"],"prefix":"10.1136","volume":"2014","author":[{"given":"Edward","family":"Tobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basant K","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"2025042702450114000_2014.feb27_1.bcr2013202157.1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.09.21"},{"key":"2025042702450114000_2014.feb27_1.bcr2013202157.2","doi-asserted-by":"crossref","unstructured":"Tobe E . Progressive neuropsychiatric and brain abnormalities after smoke inhalation. BMJ Case Rep. Published online: 9 Aug 2012. doi:10.1136\/bcr-02-2012-5945","DOI":"10.1136\/bcr-02-2012-5945"},{"key":"2025042702450114000_2014.feb27_1.bcr2013202157.3","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","article-title":"Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus","volume":"16","author":"Nibuya","year":"1996","journal-title":"J Neurosci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-202157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:45:10Z","timestamp":1745747110000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-202157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":3,"alternative-id":["10.1136\/bcr-2013-202157"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-202157","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,2,27]]}}}