{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:10Z","timestamp":1761895810312,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Cancers of the bladder could be treated with intravesical instillation of BCG therapy. This treatment could lead to some complications. Osteoarticular ones are relatively uncommon. We describe an original observation, illustrating the development of reactive arthritis after intravesical BCG therapy. A 60-year-old man was followed for a T1G3 transitional papillary carcinoma of the bladder and was treated with intravesical BCG immunotherapy. Within the sixth intravesical instillation, he presented with polyarthritis confirmed by musculoskeletal ultrasound. The erythrocyte sedimentation rate was 100\u2005mm without leukocytosis. The viral and bacterial serologies and immunological tests were negative. The ophthalmological examination revealed left conjunctivitis. Treatment with non-steroidal anti-inflammatory drugs was started, combined with the discontinuation of the intravesical instillation. No recurrence has been reported with a current decline of 2\u2005years.<\/jats:p>","DOI":"10.1136\/bcr-2013-202741","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T06:07:22Z","timestamp":1391753242000},"page":"bcr2013202741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Reactive arthritis induced by intravesical BCG therapy for bladder cancer"],"prefix":"10.1136","volume":"2014","author":[{"given":"Kaouther","family":"Ben Abdelghani","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Mongi Slim Hospital, La Marsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alia","family":"Fazaa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mongi Slim Hospital, La Marsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Souabni","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mongi Slim Hospital, La Marsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leith","family":"Zakraoui","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Mongi Slim Hospital, La Marsa, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh030"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0022-5347(17)45606-0","article-title":"Complications of bacillus Calmette\u2013Guerin immunotherapy in 1278 patients with bladder cancer","volume":"135","author":"Lamm","year":"1986","journal-title":"J Urol"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0022-5347(17)37316-0","article-title":"Incidence and treatment of complications of bacillus Calmette\u2013Guerin intravesical therapy in superficial bladder cancer","volume":"147","author":"Lamm","year":"1992","journal-title":"J Urol"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4401(01)00085-7"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2010.01.010"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.6","first-page":"458","article-title":"\u00c9valuation de la tol\u00e9rance de la BCG th\u00e9rapie endov\u00e9sicale en France: analyse des \u00e9v\u00e8nements ind\u00e9sirables graves notifi\u00e9s sur une p\u00e9riode de trois ans","volume":"11","author":"Debois","year":"2001","journal-title":"ProgUrol"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.017"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.8","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.151.ai1ofr2"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.9","first-page":"1699","article-title":"Remitting seronegative symmetrical synovitis with pitting edema following intravesical bacillus Calmette-Guerin instillation","volume":"28","author":"Mouly","year":"2001","journal-title":"J Rheumatol"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0157-2"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00271878","article-title":"The mycobacterial 65 kD heat-shock protein and autoimmune arthritis","volume":"9","author":"Van Eden","year":"1989","journal-title":"Rheumatol Int"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.01.018"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0059-2"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.14","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0022-5347(17)36973-2","article-title":"Impaired immune response by Isoniazid treatment during intravesical BCG administration in the guinea pig","volume":"148","author":"De Boer","year":"1992","journal-title":"J Urol"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.24899"},{"key":"2025082802591535000_2014.feb06_2.bcr2013202741.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01735.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-202741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:59:24Z","timestamp":1756375164000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-202741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":16,"alternative-id":["10.1136\/bcr-2013-202741"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-202741","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,2,7]]}}}